TopFIND 4.0

Q61139: Proprotein convertase subtilisin/kexin type 7

General Information

Protein names
- Proprotein convertase subtilisin/kexin type 7
- 3.4.21.-
- Prohormone convertase 7
- Proprotein convertase 7
- PC7
- Subtilisin-like proprotein convertase 7
- SPC7
- Subtilisin/kexin-like protease PC7
Gene names Pcsk7
Organism Mus musculus
Protease Family S08.077
Protease ID S08.077
Chromosome location
UniProt ID Q61139

2

N-termini

1

C-termini

0

Cleavages

10

Substrates

Sequence

        10         20         30         40         50         60 
MPKGRQKVPH LDAHLGLPIC LWLELAIFFL VPQVMGLSEA GGLDILGTGG LSWAVHLDSL 
        70         80         90        100        110        120 
EGERKEESLT QQADAVAQAA GLVNAGRIGE LQGHYLFVQP TGHRQAMEVE AMRQQAEAVL 
       130        140        150        160        170        180 
ARHEAVRWHS EQTLLKRAKR SIHFNDPKYP QQWHLNNRRS PGRDINVTGV WERNVTGRGV 
       190        200        210        220        230        240 
TVVVVDDGVE HTVQDIAPNY SPEGSYDLNS NDPDPMPHPD EENGNHHGTR CAGEIAAVPN 
       250        260        270        280        290        300 
NSFCAVGVAY GSRIAGIRVL DGPLTDSMEA VAFNKHYQIN DIYSCSWGPD DDGKTVDGPH 
       310        320        330        340        350        360 
QLGKAALQHG VMAGRQGFGS IFVVASGNGG QHNDNCNYDG YANSIYTVTI GAVDEEGRMP 
       370        380        390        400        410        420 
FYAEECASML AVTFSGGDKM LRSIVTTDWD LQKGTGCTEG HTGTSAAAPL AAGMIALMLQ 
       430        440        450        460        470        480 
VRPCLTWRDV QHIIVFTAIQ YEDHHADWLT NEAGFSHSHQ HGFGLLNAWR LVNAAKIWTS 
       490        500        510        520        530        540 
VPYLASYVSP MLKENKAVPR SPHSLEVLWN VSRTDLEMSG LKTLEHVAVT VSITHPRRGS 
       550        560        570        580        590        600 
LELKLFCPSG MMSLIGAPRS MDSDPNGFNA WTFSTVRCWG ERARGVYRLV IRDVGDEPLQ 
       610        620        630        640        650        660 
MGILQQWQLT LYGSMWSPVD IKDRQSLLES AMSGKYLHDG FTLPCPPGLK IPEEDGYTIT 
       670        680        690        700        710        720 
PNTLKTLVLV GCFSVFWTIY YMLEVCLSQR NKASTHGCRK GCCPWAPRRQ NSKDAGTALE 
       730        740        750        760        770    
SMPLCSSKDL DGVDSEHGDC TTASSFLAPE LDCPPHQPPD LLQGKSGQIC 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 10 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SGQIC 770 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates