P26339: Chromogranin-A

General Information

Protein names	- Chromogranin-A - CgA - Pancreastatin - Beta-granin - WE-14 - Catestatin - GE-25 - Serpinin-RRG - Serpinin {ECO:0000303\|PubMed:21436258, ECO:0000303\|PubMed:21537909} - AL26 {ECO:0000303\|PubMed:21436258} - p-Glu serpinin precursor {ECO:0000303\|PubMed:21537909}
Gene names	Chga
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P26339

7 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSTAVLALL LCAGQVFALP VNSPMTKGDT KVMKCVLEVI SDSLSKPSPM PVSPECLETL
        70         80         90        100        110        120
QGDERILSIL RHQNLLKELQ DLALQGAKER AQQPLKQQQP PKQQQQQQQQ QQQEQQHSSF
       130        140        150        160        170        180
EDELSEVFEN QSPDAKHRDA AAEVPSRDTM EKRKDSDKGQ QDGFEATTEG PRPQAFPEPN
       190        200        210        220        230        240
QESPMMGDSE SPGEDTATNT QSPTSLPSQE HVDPQATGDS ERGLSAQQQA RKAKQEEKEE
       250        260        270        280        290        300
EEEEEAVARE KAGPEEVPTA ASSSHFHAGY KAIQKDDGQS DSQAVDGDGK TEASEALPSE
       310        320        330        340        350        360
GKGELEHSQQ EEDGEEAMVG TPQGLFPQGG KGRELEHKQE EEEEEEERLS REWEDKRWSR
       370        380        390        400        410        420
MDQLAKELTA EKRLEGEDDP DRSMKLSFRT RAYGFRDPGP QLRRGWRPSS REDSVEARSD
       430        440        450        460
FEEKKEEEGS ANRRAEDQEL ESLSAIEAEL EKVAHQLQAL RRG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P26339-19-unknown	LPVNSP...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P26339-358-unknown	WSRMDQ...	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34703
P26339-374-unknown	LEGEDD...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34704
P26339-388-unknown	FRTRAY...	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31446
P26339-392-unknown	AYGFRD...	392	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34705
P26339-402-unknown	LRRGWR...	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31447
P26339-405-unknown	GWRPSS...	405	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34706

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WEDKRW	357	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34703
...TAEKRL	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34704
...SMKLSF	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31446
...SFRTRA	391	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34705
...DPGPQL	401	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31447
...PQLRRG	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34706
...ALRRG	463	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	357	DKRW.\|.WSRM	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	373	EKRL.\|.LEGE	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
CBPA4_MOUSE	387	KLSF.\|.FRTR	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
NEC2_MOUSE	391	RTRA.\|.AYGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
CBPA4_MOUSE	401	GPQL.\|.LRRG	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
NEC2_MOUSE	404	LRRG.\|.GWRP	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)