Q03517: Secretogranin-2

General Information

Protein names	- Secretogranin-2 - Chromogranin-C - Secretogranin II - SgII - Secretoneurin - SN - Manserin
Gene names	Scg2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03517

5 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGAKAYRLG AVLLLIHLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE
        70         80         90        100        110        120
YIEKLRQQAH REESSPDYNP YQGVSVPLQL KENGEESHLA ESSRDALSED EWMRIILEAL
       130        140        150        160        170        180
RQAENEPPSA PKENKPYALN LEKNFPVDTP DDYETQQWPE RKLKHMRFPL MYEENSRENP
       190        200        210        220        230        240
FKRTNEIVEE QYTPQSLATL ESVFQELGKL TGPSNQKRER VDEEQKLYTD DEDDVYKTNN
       250        260        270        280        290        300
IAYEDVVGGE DWSPIEEKIE TQTQEEVRDS KENTEKNEQI NEEMKRSGQL GLPDEENRRE
       310        320        330        340        350        360
SKDQLSEDAS KVITYLRRLV NAVGSGRSQS GPNGDRAARL LQKPLDSQSI YQLIEISRNL
       370        380        390        400        410        420
QIPPEDLIEM LKAGEKPNGL VEPEQDLELA VDLDDIPEAD LDRPDMFQSK MLSKGGYPKA
       430        440        450        460        470        480
PGRGMVEALP DGLSVEDILN VLGMENVVNQ KSPYFPNQYS QDKALMRLPY GPGKSRANQI
       490        500        510        520        530        540
PKVAWIPDVE SRQAPYENLN DQELGEYLAR MLVKYPELLN TNQLKRVPSP VSSEDDLQEE
       550        560        570        580        590        600
EQLEQAIKEH LGPGSSQEME RLAKVSKRIP VGSLKNEDTP NRQYLDEDML LKVLEYLNQE
       610
QAEQGREHLA KRAMENM

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q03517-31-unknown	QRNQLL...	31	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q03517-31-unknown	QRNQLL...	31	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q03517-184-unknown	TNEIVE...	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34728
Q03517-219-unknown	ERVDEE...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34729
Q03517-316-unknown	LRRLVN...	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31496
Q03517-316-unknown	LRRLVN...	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31451
Q03517-569-unknown	IPVGSL...	569	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34730

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NPFKRT	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34728
...SNQKRE	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34729
...KVITYL	315	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31496
...KVITYL	315	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31451
...KVSKRI	568	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34730
...HLAKRA	612	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34731
...AMENM	617	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	183	FKRT.\|.TNEI	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	218	QKRE.\|.ERVD	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
CBPA6_MOUSE	315	ITYL.\|.LRRL	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Substrate specificity of human ... (M14.018)	20855895,
CBPA4_MOUSE	315	ITYL.\|.LRRL	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
NEC2_MOUSE	568	SKRI.\|.IPVG	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	612	AKRA.\|.AMEN	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)