Q64387: Prepronociceptin

General Information

Protein names	- Prepronociceptin - N23K/N27K - Nocistatin - Nociceptin - Orphanin FQ - PPNOC - Orphanin FQ2
Gene names	Pnoc
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q64387

7 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKILFCDVLL LSLLSSVFSS CPRDCLTCQE KLHPAPDSFN LKTCILQCEE KVFPRPLWTV
        70         80         90        100        110        120
CTKVMASGSG QLSPADPELV SAALYQPKAS EMQHLKRMPR VRSLVQVRDA EPGADAEPGA
       130        140        150        160        170        180
DAEPGADDAE EVEQKQLQKR FGGFTGARKS ARKLANQKRF SEFMRQYLVL SMQSSQRRRT

LHQNGNV

Isoforms

- Isoform Long of Prepronociceptin

Sequence View

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Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q64387-1-unknown	MKILFC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85701
Q64387-20-unknown	SCPRDC...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q64387-20-unknown	SCPRDC...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112362
Q64387-141-unknown	FGGFTG...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34734
Q64387-141-unknown	FGGFTG...	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144374
Q64387-142-unknown	GGFTGA...	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34800
Q64387-142-unknown	GGFTGA...	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144428
Q64387-148-unknown	RKSARK...	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34802
Q64387-148-unknown	RKSARK...	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144658
Q64387-152-unknown	RKLANQ...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34804
Q64387-152-unknown	RKLANQ...	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144838
Q64387-160-unknown	FSEFMR...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34736
Q64387-160-unknown	FSEFMR...	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145148

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QLQKRF	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34734
...QLQKRF	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127636
...LQKRFG	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34800
...LQKRFG	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127692
...GFTGAR	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34802
...GFTGAR	147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127925
...ARKSAR	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34804
...ARKSAR	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128114
...ANQKRF	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34736
...ANQKRF	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128435

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	140	QKRF.\|.FGGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
THOP1_MOUSE	141	KRFG.\|.GGFT	inferred from experiment	unknown	MEROPS	Noble F	Montiel JL et al.:Nociceptin/orphanin FQ metaboli... (M03.001)	8978746,
THOP1_MOUSE	147	TGAR.\|.RKSA	inferred from experiment	unknown	MEROPS	Noble F	Montiel JL et al.:Nociceptin/orphanin FQ metaboli... (M03.001)	8978746,
THOP1_MOUSE	151	KSAR.\|.RKLA	inferred from experiment	unknown	MEROPS	Noble F	Montiel JL et al.:Nociceptin/orphanin FQ metaboli... (M03.001)	8978746,
NEC2_MOUSE	159	QKRF.\|.FSEF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)