P22005: Proenkephalin-A

General Information

Protein names	- Proenkephalin-A - Synenkephalin - Met-enkephalin - Opioid growth factor - OGF - PENK(114-133) - PENK(143-184) - Met-enkephalin-Arg-Ser-Leu - Leu-enkephalin - PENK(238-259) - Met-enkephalin-Arg-Phe
Gene names	Penk
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P22005

8 N-termini

10 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MARFLRLCTW LLALGSCLLA TVQAECSQDC AKCSYRLVRP GDINFLACTL ECEGQLPSFK
        70         80         90        100        110        120
IWETCKDLLQ VSRPEFPWDN IDMYKDSSKQ DESHLLAKKY GGFMKRYGGF MKKMDELYPM
       130        140        150        160        170        180
EPEEEANGGE ILAKRYGGFM KKDADEGDTL ANSSDLLKEL LGTGDNRAKD SHQQESTNND
       190        200        210        220        230        240
EDMSKRYGGF MRSLKRSPQL EDEAKELQKR YGGFMRRVGR PEWWMDYQKR YGGFLKRFAE
       250        260
SLPSDEEGEN YSKEVPEIEK RYGGFMRF

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P22005-187-unknown	YGGFMR...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34695
P22005-197-unknown	SPQLED...	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34696
P22005-198-unknown	PQLEDE...	198	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34697
P22005-211-unknown	YGGFMR...	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34698
P22005-218-unknown	VGRPEW...	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34699
P22005-231-unknown	YGGFLK...	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34700
P22005-239-unknown	AESLPS...	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34701
P22005-262-unknown	YGGFMR...	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34702

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QESTNN	178	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122389
...DMSKRY	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34695
...RSLKRS	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34696
...SLKRSP	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34697
...ELQKRY	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34698
...GFMRRV	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34699
...DYQKRY	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34700
...FLKRFA	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34701
...EIEKRY	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34702
...GGFMRF	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31445

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	186	SKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	196	LKRS.\|.SPQL	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	197	KRSP.\|.PQLE	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	210	QKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	217	MRRV.\|.VGRP	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	230	QKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	238	KRFA.\|.AESL	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	261	EKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
CBPA4_MOUSE	267	FMRF.\|.F	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,

TopFIND

P22005: Proenkephalin-A

General Information

8

N-termini

10

C-termini

9

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

8 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates