P41539: Protachykinin-1

General Information

Protein names	- Protachykinin-1 - PPT - Substance P - Neurokinin A - NKA - Neuromedin L - Substance K - Neuropeptide K - NPK - Neuropeptide gamma - C-terminal-flanking peptide
Gene names	Tac1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P41539

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKILVAVAVF FLVSTQLFAE EIDANDDLNY WSDWSDSDQI KEAMPEPFEH LLQRIARRPK
        70         80         90        100        110        120
PQQFFGLMGK RDADSSVEKQ VALLKALYGH GQISHKRHKT DSFVGLMGKR ALNSVAYERS
       130
AMQNYERRRK

Isoforms

- Isoform Gamma of Protachykinin-1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P41539-1-unknown	MKILVA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92219
P41539-20-unknown	EEIDAN...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P41539-20-unknown	EEIDAN...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112397
P41539-58-unknown	RPKPQQ...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34707
P41539-72-unknown	DADSSV...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34709
P41539-98-unknown	HKTDSF...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34710
P41539-98-unknown	HKTDSF...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196917
P41539-111-unknown	ALNSVA...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34711
P41539-111-unknown	ALNSVA...	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142199

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QRIARR	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34707
...QRIARR	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122850
...LMGKRD	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34709
...LMGKRD	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154052
...ISHKRH	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34710
...LMGKRA	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34711
...LMGKRA	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125387
...LMGKRA	110	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LMGKRA	110	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
...ERRRK	130	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87837

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	57	IARR.\|.RPKP	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	71	GKRD.\|.DADS	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	97	HKRH.\|.HKTD	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	110	GKRA.\|.ALNS	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)