P01193: Pro-opiomelanocortin

General Information

Protein names	- Pro-opiomelanocortin - POMC - Corticotropin-lipotropin - NPP - Melanotropin gamma - Gamma-MSH - Corticotropin - Adrenocorticotropic hormone - ACTH - Melanocyte-stimulating hormone alpha - Alpha-MSH - Melanotropin alpha - Corticotropin-like intermediary peptide - CLIP - Lipotropin beta - Beta-LPH - Lipotropin gamma - Gamma-LPH - Melanocyte-stimulating hormone beta - Beta-MSH - Melanotropin beta - Beta-endorphin - Met-enkephalin
Gene names	Pomc
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P01193

7 N-termini

7 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC KLDLSLETPV
        70         80         90        100        110        120
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ RRAEEEAVWG DGSPEPSPRE
       130        140        150        160        170        180
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGER PLGLEQVLES
       190        200        210        220        230
DAEKDDGPYR VEHFRWSNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01193-27-unknown	WCLESS...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01193-27-unknown	WCLESS...	27	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P01193-76-unknown	KYVMGH...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34672
P01193-103-unknown	AEEEAV...	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34673
P01193-124-unknown	SYSMEH...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34648
P01193-124-unknown	SYSMEH...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34674
P01193-141-unknown	RPVKVY...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34675
P01193-165-unknown	ELEGER...	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34649
P01193-165-unknown	ELEGER...	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34676
P01193-205-unknown	YGGFMT...	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34650
P01193-205-unknown	YGGFMT...	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34677

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TENPRK	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34672
...AAQRRA	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34673
...REGKRS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34648
...REGKRS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34674
...VGKKRR	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34675
...LEFKRE	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34649
...LEFKRE	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34676
...PKDKRY	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34650
...PKDKRY	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34677
...NAHKKG	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34651
...NAHKKG	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34678

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	75	NPRK.\|.KYVM	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
NEC2_MOUSE	102	QRRA.\|.AEEE	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC1_MOUSE	123	GKRS.\|.SYSM	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC2_MOUSE	123	GKRS.\|.SYSM	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC2_MOUSE	140	KKRR.\|.RPVK	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC1_MOUSE	164	FKRE.\|.ELEG	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC2_MOUSE	164	FKRE.\|.ELEG	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC1_MOUSE	204	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC2_MOUSE	204	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
NEC1_MOUSE	233	HKKG.\|.GQ	inferred from experiment	unknown	MEROPS		Merops NEC1_MOUSE -> COLI_MOUSE @233
NEC2_MOUSE	233	HKKG.\|.GQ	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,

TopFIND

P01193: Pro-opiomelanocortin

General Information

7

N-termini

7

C-termini

11

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 11 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates