P55095: Glucagon

General Information

Protein names	- Glucagon - Glicentin - Glicentin-related polypeptide - GRPP - Oxyntomodulin - OXM - OXY - Glucagon - Glucagon-like peptide 1 - GLP-1 - Glucagon-like peptide 1(7-37) - GLP-1(7-37) - Glucagon-like peptide 1(7-36) - GLP-1(7-36) - Glucagon-like peptide 2 - GLP-2
Gene names	Gcg
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P55095

10 N-termini

10 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKTIYFVAGL LIMLVQGSWQ HALQDTEENP RSFPASQTEA HEDPDEMNED KRHSQGTFTS
        70         80         90        100        110        120
DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI
       130        140        150        160        170        180
AWLVKGRGRR DFPEEVAIAE ELGRRHADGS FSDEMSTILD NLATRDFINW LIQTKITDKK

Isoforms

Sequence View

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P55095-21-unknown	HALQDT...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55095-21-unknown	HALQDT...	21	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P55095-53-unknown	HSQGTF...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34714
P55095-69-unknown	RRAQDF...	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34747
P55095-70-unknown	RAQDFV...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28013
P55095-71-unknown	AQDFVQ...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28014
P55095-84-unknown	NRNNIA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34661
P55095-84-unknown	NRNNIA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34715
P55095-92-unknown	HDEFER...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34662
P55095-98-unknown	HAEGTF...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34663
P55095-131-unknown	DFPEEV...	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34664
P55095-146-unknown	HADGSF...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34665
P55095-146-unknown	HADGSF...	146	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55095-146-unknown	HADGSF...	146	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

Name

Sequence

Position

Modification

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMID)

P55095-21-unknown

HALQDT...

inferred from electronic annotation

electronic annotation

UniProtKB

inferred from uniprot

P55095-21-unknown

HALQDT...

inferred from similarity

unknown

UniProtKB

inferred from uniprot (by similarity)

P55095-53-unknown

HSQGTF...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34714

P55095-69-unknown

RRAQDF...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34747

P55095-70-unknown

RAQDFV...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC28013

P55095-71-unknown

AQDFVQ...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC28014

P55095-84-unknown

NRNNIA...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34661

P55095-84-unknown

NRNNIA...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34715

P55095-92-unknown

HDEFER...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34662

P55095-98-unknown

HAEGTF...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34663

P55095-131-unknown

DFPEEV...

131

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34664

P55095-146-unknown

HADGSF...

146

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC34665

P55095-146-unknown

HADGSF...

146

inferred from electronic annotation

electronic annotation

UniProtKB

inferred from uniprot

P55095-146-unknown

HADGSF...

146

inferred from similarity

unknown

UniProtKB

inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NEDKRH	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34714
...KYLDSR	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34747
...YLDSRR	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28013
...LDSRRA	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28014
...MNTKRN	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34661
...MNTKRN	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34715
...NIAKRH	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34662
...DEFERH	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34663
...GRGRRD	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34664
...ELGRRH	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34665
...NWLIQT	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115892

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	52	DKRH.\|.HSQG	inferred from experiment	unknown	MEROPS	Noe BD	Rothenberg ME et al.:Processing of mouse proglucagon... (S08.073)	7730317,
NRDC_MOUSE	68	LDSR.\|.RRAQ	inferred from experiment	unknown	MEROPS	Bataille D	Fontes G et al.:Miniglucagon (MG)-generating en... (M01.014)	15539558,
AMPB_MOUSE	69	DSRR.\|.RAQD	inferred from experiment	unknown	MEROPS	Bataille D	Fontes G et al.:Miniglucagon (MG)-generating en... (M01.014)	15539558,
AMPB_MOUSE	70	SRRA.\|.AQDF	inferred from experiment	unknown	MEROPS	Bataille D	Fontes G et al.:Miniglucagon (MG)-generating en... (M01.014)	15539558,
NEC1_MOUSE	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS		Merops NEC1_MOUSE -> GLUC_MOUSE @83
NEC2_MOUSE	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
NEC1_MOUSE	91	AKRH.\|.HDEF	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
NEC1_MOUSE	97	FERH.\|.HAEG	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
NEC1_MOUSE	130	GRRD.\|.DFPE	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
NEC1_MOUSE	145	GRRH.\|.HADG	inferred from in-silico analysis	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,

Protease

Position

Sequence

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMIDs)

NEC2_MOUSE

DKRH.|.HSQG

inferred from experiment