P00796: Renin-2

General Information

Protein names	- Renin-2 - 3.4.23.15 - Angiotensinogenase - Submandibular gland renin - Renin-2 heavy chain - Renin-2 light chain
Gene names	Ren2
Organism	Mus musculus
Protease Family	A01.008
Protease ID	A01.008
Chromosome location
UniProt ID	P00796

4 N-termini

4 C-termini

5 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MDRRRMPLWA LLLLWSPCTF SLPTGTTFER IPLKKMPSVR EILEERGVDM TRLSAEWDVF
        70         80         90        100        110        120
TKRSSLTDLI SPVVLTNYLN SQYYGEIGIG TPPQTFKVIF DTGSANLWVP STKCSRLYLA
       130        140        150        160        170        180
CGIHSLYESS DSSSYMENGD DFTIHYGSGR VKGFLSQDSV TVGGITVTQT FGEVTELPLI
       190        200        210        220        230        240
PFMLAQFDGV LGMGFPAQAV GGVTPVFDHI LSQGVLKEKV FSVYYNRGPH LLGGEVVLGG
       250        260        270        280        290        300
SDPEHYQGDF HYVSLSKTDS WQITMKGVSV GSSTLLCEEG CEVVVDTGSS FISAPTSSLK
       310        320        330        340        350        360
LIMQALGAKE KRLHEYVVSC SQVPTLPDIS FNLGGRAYTL SSTDYVLQYP NRRDKLCTVA
       370        380        390        400
LHAMDIPPPT GPVWVLGATF IRKFYTEFDR HNNRIGFALA R

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 5 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00796-26-unknown	TTFERI...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00796-63-unknown	RSSLTD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32647
P00796-64-unknown	SSLTDL...	64	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00796-64-unknown	SSLTDL...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34647
P00796-64-unknown	SSLTDL...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32648
P00796-64-unknown	SSLTDL...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32649
P00796-64-unknown	SSLTDL...	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32662
P00796-354-unknown	DKLCTV...	354	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DVFTKR	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32647
...VFTKRS	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34647
...VFTKRS	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32648
...VFTKRS	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32649
...VFTKRS	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32662
...LQYPNR	351	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FALAR	401	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
K1B22_MOUSE	62	FTKR.\|.RSSL	inferred from experiment	unknown	MEROPS	Hosoi K	Kikkawa Y et al.:Prorenin processing and restric... (S01.039)	9507064,
NEC1_MOUSE	63	TKRS.\|.SSLT	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
K1B22_MOUSE	63	TKRS.\|.SSLT	inferred from experiment	unknown	MEROPS	Hosoi K	Kikkawa Y et al.:Prorenin processing and restric... (S01.039)	9507064,
K1B26_MOUSE	63	TKRS.\|.SSLT	inferred from experiment	unknown	MEROPS		Merops K1B26_MOUSE -> RENI2_MOUSE @63
K1KB9_MOUSE	63	TKRS.\|.SSLT	inferred from experiment	unknown	MEROPS	Hosoi K	Kikkawa Y et al.:Prorenin processing and restric... (S01.039)	9507064,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_MOUSE	34	FHLL.\|.LYHN	inferred from experiment	unknown	MEROPS		Merops RENI2_MOUSE -> ANGT_MOUSE @34