Q8VEE4: Replication protein A 70 kDa DNA-binding subunit

General Information

Protein names	- Replication protein A 70 kDa DNA-binding subunit - RP-A p70 - Replication factor A protein 1 - RF-A protein 1
Gene names	Rpa1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8VEE4

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVGHLSEGAI EVMIQQENTS IKPILQVINI RPISTGNRSP RYRLLMSDGL NTLSSFMLAT
        70         80         90        100        110        120
QLNTLVEGGQ LASNCVCQVH KFIVNTLKDG RKVVVLMDLE VMKSAEDVGL KIGNPVPYNE
       130        140        150        160        170        180
GYGQQQQQQQ QQQQQAVPSP ASAATPPASK PQPQNGSLGM GSTAAKAYGA SKPFGKPAGT
       190        200        210        220        230        240
GLLQPSGGTQ SKVVPIASLT PYQSKWTICA RVTNKSQIRT WSNSRGEGKL FSLELVDESG
       250        260        270        280        290        300
EIRATAFNEQ VDKFFPLIEV NKVYYFSKGA LKIANKQFSA VKNDYEMTFN NETSVLPCED
       310        320        330        340        350        360
GHHLPTVQFD FTGIGDLESK AKDALVDIIG ICKSYEDSIK ITVKSNNREV AKRNIYLMDM
       370        380        390        400        410        420
SGKVVTTTLW GEDADKFDGS RQPVMAIKGA RVSDFGGRSL SVLSSSTVIV NPDIPEAYKL
       430        440        450        460        470        480
RGWFDSEGQA LDGVSISDHR SGGAGGGNTN WKTLHEAKSE NLGQGDKADY FSTVAAVVFL
       490        500        510        520        530        540
RKENCMYQAC PTQDCNKKVI DQQNGLYRCE KCDREFPNFK YRMILSANIA DFQENQWVTC
       550        560        570        580        590        600
FQESAEAILG QNTMYLGELK EKNEQAFEEV FQNANFRSFT FRIRVKLETY NDESRIKATV
       610        620
MDVKPVDFRD YGRRLIANIR KNM

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q8VEE4-1-Acetylation	MVGHLS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8VEE4-2-Acetylation	MVGHLS...	1	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8VEE4-2-unknown	VGHLSE...	2		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8VEE4-2-unknown	VGHLSE...	2		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8VEE4-108-unknown	VGLKIG...	108		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8VEE4-369-unknown	LWGEDA...	369		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34124
Q8VEE4-559-unknown	LKEKNE...	559		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34125

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVTTTL	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34124
...MYLGEL	558	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34125
...IRKNM	623	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	368	TTTL.\|.LWGE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	558	LGEL.\|.LKEK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)