P26039: Talin-1

General Information

Protein names	- Talin-1
Gene names	Tln1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P26039

23 N-termini

23 C-termini

22 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVALSLKISI GNVVKTMQFE PSTMVYDACR MIRERIPEAL AGPPNDFGLF LSDDDPKKGI
        70         80         90        100        110        120
WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG
       130        140        150        160        170        180
ITNHDEYSLV RELMEEKKDE GTGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL
       190        200        210        220        230        240
REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG
       250        260        270        280        290        300
FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK
       310        320        330        340        350        360
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WSLTNIKRWA
       370        380        390        400        410        420
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML
       430        440        450        460        470        480
EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM
       490        500        510        520        530        540
HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFETLP PLGQDAASKA WRKNKMDESK
       550        560        570        580        590        600
HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED
       610        620        630        640        650        660
EGGNGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT
       670        680        690        700        710        720
DPHFQDVLMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT QVIAAATQCA LSTSQLVACT
       730        740        750        760        770        780
KVVAPTISSP VCQEQLVEAG RLVAKAVEGC VSASQAATED GQLLRGVGAA ATAVTQALNE
       790        800        810        820        830        840
LLQHVKAHAT GAGPAGRYDQ ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI
       850        860        870        880        890        900
KADAEGESDL ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA
       910        920        930        940        950        960
TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS APKASAGPQP LLVQSCKAVA
       970        980        990       1000       1010       1020
EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM VAAAKASVPT IQDQASAMQL
      1030       1040       1050       1060       1070       1080
SQCAKNLGTA LAELRTAAQK AQEACGPLEM DSALSVVQNL EKDLQEIKAA ARDGKLKPLP
      1090       1100       1110       1120       1130       1140
GETMEKCTQD LGNSTKAVSS AIAKLLGEIA QGNENYAGIA ARDVAGGLRS LAQAARGVAA
      1150       1160       1170       1180       1190       1200
LTSDPAVQAI VLDTASDVLD KASSLIEEAK KASGHPGDPE SQQRLAQVAK AVTQALNRCV
      1210       1220       1230       1240       1250       1260
SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN QAATELVQAS
      1270       1280       1290       1300       1310       1320
RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ VVSNLKGISM SSSKLLLAAK
      1330       1340       1350       1360       1370       1380
ALSTDPASPN LKSQLAAAAR AVTDSINQLI TMCTQQAPGQ KECDNALRQL ETVRELLENP
      1390       1400       1410       1420       1430       1440
VQPINDMSYF GCLDSVMENS KVLGEAMTGI SQNAKNGNLP EFGDAIATAS KALCGFTEAA
      1450       1460       1470       1480       1490       1500
AQAAYLVGVS DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK
      1510       1520       1530       1540       1550       1560
HTSALCNSCR LASARTANPT AKRQFVQSAK EVANSTANLV KTIKALDGDF TEENRAQCRA
      1570       1580       1590       1600       1610       1620
ATAPLLEAVD NLSAFASNPE FSSVPAQISP EGRAAMEPIV ISAKTMLESA GGLIQTARAL
      1630       1640       1650       1660       1670       1680
AVNPRDPPRW SVLAGHSRTV SDSIKKLITS MRDKAPGQLE CETAIAALNS CLRDLDQASL
      1690       1700       1710       1720       1730       1740
AAVSQQLAPR EGISQEALHT QMLTAVQEIS HLIEPLASAA RAEASQLGHK VSQMAQYFEP
      1750       1760       1770       1780       1790       1800
LTLAAVGAAS KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV
      1810       1820       1830       1840       1850       1860
QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGDPEGSF VDYQTTMVRT
      1870       1880       1890       1900       1910       1920
AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASQA KPAAVAAENE EIGAHIKHRV
      1930       1940       1950       1960       1970       1980
QELGHGCSAL VTKAGALQCS PSDVYTKKEL IECARRVSEK VSHVLAALQA GNRGTQACIT
      1990       2000       2010       2020       2030       2040
AASAVSGIIA DLDTTIMFAT AGTLNREGAE TFADHREGIL KTAKVLVEDT KVLVQNAAGS
      2050       2060       2070       2080       2090       2100
QEKLAQAAQS SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA
      2110       2120       2130       2140       2150       2160
AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT EHIRQELAVF
      2170       2180       2190       2200       2210       2220
CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED VIATANLSRR AIADMLRACK
      2230       2240       2250       2260       2270       2280
EAAFHPEVAP DVRLRALHYG RECANGYLEL LDHVLLTLQK PNPDLKQQLT GHSKRVAGSV
      2290       2300       2310       2320       2330       2340
TELIQAAEAM KGTEWVDPED PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN
      2350       2360       2370       2380       2390       2400
FEEQILEAAK SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV
      2410       2420       2430       2440       2450       2460
AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS EAMKRLQAAG
      2470       2480       2490       2500       2510       2520
NAVKRASDNL VKAAQKAAAF EDQENETVVV KEKMVGGIAQ IIAAQEEMLR KERELEEARK
      2530       2540
KLAQIRQQQY KFLPSELRDE H

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

23 N-termini - 23 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26039-1-unknown	MVALSL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26039-86-unknown	RPLKIR...	86	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P26039-134-unknown	MEEKKD...	134	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28836
P26039-270-unknown	YVKQKG...	270	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28837
P26039-271-unknown	VKQKGE...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29862
P26039-371-unknown	GDYQDG...	371	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P26039-423-unknown	SVSPKK...	423	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29863
P26039-425-unknown	SPKKST...	425	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28352
P26039-428-unmodified	KSTVLQ...	428		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26039-807-unknown	TVTENI...	807	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28838
P26039-807-unknown	TVTENI...	807	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29864
P26039-830-unknown	AQATSD...	830	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29865
P26039-1573-unknown	SAFASN...	1573	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28839
P26039-1607-unknown	LESAGG...	1607	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29866
P26039-1608-unknown	ESAGGL...	1608	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28840
P26039-1851-unknown	VDYQTT...	1851	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29867
P26039-1966-unknown	AALQAG...	1966	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29868
P26039-1998-unknown	FATAGT...	1998	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28841
P26039-1998-unknown	FATAGT...	1998	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29869
P26039-2034-unknown	VQNAAG...	2034	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28842
P26039-2034-unknown	VQNAAG...	2034	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29870
P26039-2129-unknown	LKTVKA...	2129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28843
P26039-2146-unknown	LEATTE...	2146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33468
P26039-2185-unknown	ATAKAV...	2185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29871
P26039-2201-unknown	VIATAN...	2201	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29872
P26039-2501-unknown	IIAAQE...	2501	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33469

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVRELM	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28836
...EFAGFQ	241	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119441
...FLPKEY	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28837
...LPKEYV	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29862
...TMLEDS	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29863
...LEDSVS	424	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28352
...TDTILT	806	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28838
...TDTILT	806	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29864
...QARILA	829	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29865
...ESDLEN	851	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115681
...SQSFLQ	994	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119956
...AVDNLS	1572	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28839
...SAKTML	1606	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29866
...AKTMLE	1607	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28840
...PEGSFV	1850	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29867
...VSHVLA	1965	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29868
...DTTIMF	1997	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28841
...DTTIMF	1997	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29869
...DTKVLV	2033	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28842
...DTKVLV	2033	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29870
...NVTSLL	2128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28843
...KGTRAL	2145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33468
...KGITMA	2184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29871
...CRQEDV	2200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29872
...GGIAQI	2500	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33469
...LRDEH	2541	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	133	RELM.\|.MEEK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @133
CATD_MOUSE	269	PKEY.\|.YVKQ	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @269
CATE_MOUSE	270	KEYV.\|.VKQK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @270
CATE_MOUSE	422	LEDS.\|.SVSP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @422
CASP1_MOUSE	424	DSVS.\|.SPKK	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CATD_MOUSE	806	TILT.\|.TVTE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @806
CATE_MOUSE	806	TILT.\|.TVTE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @806
CATE_MOUSE	829	RILA.\|.AQAT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @829
CATD_MOUSE	1572	DNLS.\|.SAFA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @1572
CATE_MOUSE	1606	KTML.\|.LESA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @1606
CATD_MOUSE	1607	TMLE.\|.ESAG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @1607
CATE_MOUSE	1850	GSFV.\|.VDYQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @1850
CATE_MOUSE	1965	HVLA.\|.AALQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @1965
CATD_MOUSE	1997	TIMF.\|.FATA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @1997
CATE_MOUSE	1997	TIMF.\|.FATA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @1997
CATD_MOUSE	2033	KVLV.\|.VQNA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @2033
CATE_MOUSE	2033	KVLV.\|.VQNA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @2033
CATD_MOUSE	2128	TSLL.\|.LKTV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TLN1_MOUSE @2128
MMP2_MOUSE	2145	TRAL.\|.LEAT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	2184	ITMA.\|.ATAK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @2184
CATE_MOUSE	2200	QEDV.\|.VIAT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TLN1_MOUSE @2200
MMP2_MOUSE	2500	IAQI.\|.IIAA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)