TopFIND 4.0

P18242: Cathepsin D

General Information

Protein names
- Cathepsin D
- 3.4.23.5
Gene names Ctsd
Organism Mus musculus
Protease Family A01.009
Protease ID A01.009
Chromosome location
UniProt ID P18242

4

N-termini

2

C-termini

2

Cleavages

832

Substrates

Sequence

        10         20         30         40         50         60 
MKTPGVLLLI LGLLASSSFA IIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS 
        70         80         90        100        110        120 
PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KILDIACWVH 
       130        140        150        160        170        180 
HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDQSKARGI KVEKQIFGEA 
       190        200        210        220        230        240 
TKQPGIVFVA AKFDGILGMG YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG 
       250        260        270        280        290        300 
GELMLGGTDS KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV 
       310        320        330        340        350        360 
GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD KYILKVSQGG 
       370        380        390        400        410    
KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN RVGFANAVVL 

Isoforms



Sequence View



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 832 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P18242-4-unknown PGVLLL... 4 inferred from electronic annotation unknown TISdb inferred from TISdb
    P18242-21-unknown IIRIPL... 21 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P18242-65-unknown EPVSEL... 65 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P18242-76-unknown DAQYYG... 76 inferred from electronic annotation unknown TISdb inferred from TISdb

C-termini

Cleavages

Substrates