TopFIND 4.0

Q922D8: C-1-tetrahydrofolate synthase, cytoplasmic

General Information

Protein names
- C-1-tetrahydrofolate synthase, cytoplasmic
- C1-THF synthase
- Methylenetetrahydrofolate dehydrogenase
- 1.5.1.5
- Methenyltetrahydrofolate cyclohydrolase
- 3.5.4.9
- Formyltetrahydrofolate synthetase
- 6.3.4.3
- C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed
Gene names Mthfd1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q922D8

5

N-termini

3

C-termini

3

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPAGILNGK LVSAQIRDRL KNQVTRMQEQ VPGFTPGLAI LQVGDRDDSN LYINVKLKAA 
        70         80         90        100        110        120 
EEIGIKATHI KLPRTSTESE VLKYVISLNE DASVHGFIVQ LPLDSENSIN TEAVINAIAP 
       130        140        150        160        170        180 
EKDVDGLTSV SAGKLARGDL NDCFIPCTPK GCLELIKEAG VQIAGRHAVV VGRSKIVGAP 
       190        200        210        220        230        240 
MHDLLLWNNA TVTTCHSKTA NLDKEVNKGD ILVVATGQPE MVKGEWIKPG AVVIDCGINY 
       250        260        270        280        290        300 
VPDDTKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AQRFLQKFKP 
       310        320        330        340        350        360 
GKWTIQYNKL NLKTPVPSDI AISRSCKPKL IGNLAREIGL LTEEVELYGE TKAKVLLSAL 
       370        380        390        400        410        420 
DRLKHQPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LRQNVFACVR QPSQGPTFGI 
       430        440        450        460        470        480 
KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV 
       490        500        510        520        530        540 
PSVNGIRKFS DIQIRRLRRL GIEKTDPTTL TDDEINRFAR LDIDPETITW QRVLDTNDRF 
       550        560        570        580        590        600 
LRKITIGQSP TEKGHTRTAQ FDISVASEIM AVLALTSSLE DMRERLGRMV VASSKKGEPI 
       610        620        630        640        650        660 
SCEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG 
       670        680        690        700        710        720 
PEGFVVTEAG FGADIGMEKF FNIKCRYSGL QPHVVVLVAT VRALKMHGGG PTVTAGLPLP 
       730        740        750        760        770        780 
KAYTEEDLDL VEKGFSNLRK QIENARMFGV PVVVAVNVFK TDTDAELDLV SRLSREHGAF 
       790        800        810        820        830        840 
DAVKCTHWAE GGQGALALAQ AVQRASQAPS SFQLLYDLKL SIEDKIRIIA QRIYGADDIE 
       850        860        870        880        890        900 
LLPEAQNKAE IYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFVLPIRD IRASVGAGFL 
       910        920        930    
YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)