P21981: Protein-glutamine gamma-glutamyltransferase 2

General Information

Protein names	- Protein-glutamine gamma-glutamyltransferase 2 - 2.3.2.13 - Tissue transglutaminase - Transglutaminase C - TG(C) - TGC - TGase C - Transglutaminase-2 - TGase-2
Gene names	Tgm2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P21981

8 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEELLLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY EASVDSLTFG
        70         80         90        100        110        120
AVTGPDPSEE AGTKARFSLS DNVEEGSWSA SVLDQQDNVL SLQLCTPANA PIGLYRLSLE
       130        140        150        160        170        180
ASTGYQGSSF VLGHFILLYN AWCPADDVYL DSEEERREYV LTQQGFIYQG SVKFIKSVPW
       190        200        210        220        230        240
NFGQFEDGIL DTCLMLLDMN PKFLKNRSRD CSRRSSPIYV GRVVSAMVNC NDDQGVLLGR
       250        260        270        280        290        300
WDNNYGDGIS PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN
       310        320        330        340        350        360
YNSAHDQNSN LLIEYFRNEF GELESNKSEM IWNFHCWVES WMTRPDLQPG YEGWQAIDPT
       370        380        390        400        410        420
PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIRQEDG SVLKSINRSL
       430        440        450        460        470        480
VVGQKISTKS VGRDDREDIT HTYKYPEGSP EEREVFTKAN HLNKLAEKEE TGVAMRIRVG
       490        500        510        520        530        540
DSMSMGNDFD VFAHIGNDTS ETRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS
       550        560        570        580        590        600
IPLRILYEKY SGCLTESNLI KVRGLLIEPA ANSYLLAERD LYLENPEIKI RVLGEPKQNR
       610        620        630        640        650        660
KLVAEVSLKN PLSDPLYDCI FTVEGAGLTK EQKSVEVSDP VPAGDLVKAR VDLFPTDIGL
       670        680
HKLVVNFQCD KLKSVKGYRN VIIGPA

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P21981-2-unknown	MAEELL...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21981-2-Acetylation	AEELLL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21981-140-unknown	NAWCPA...	140		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P21981-421-unknown	VVGQKI...	421		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29844
P21981-582-unknown	YLENPE...	582		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29845
P21981-583-unknown	LENPEI...	583		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29846
P21981-668-unknown	QCDKLK...	668		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29847
P21981-668-unknown	QCDKLK...	668		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28826
P21981-671-unknown	KLKSVK...	671		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28827

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...INRSLV	420	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29844
...AERDLY	581	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29845
...ERDLYL	582	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29846
...LVVNFQ	667	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29847
...LVVNFQ	667	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28826
...NFQCDK	670	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28827
...IIGPA	686	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	420	RSLV.\|.VVGQ	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> TGM2_MOUSE @420
CATE_MOUSE	581	RDLY.\|.YLEN	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> TGM2_MOUSE @581
CATE_MOUSE	582	DLYL.\|.LENP	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> TGM2_MOUSE @582
CATE_MOUSE	667	VNFQ.\|.QCDK	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> TGM2_MOUSE @667
CATD_MOUSE	667	VNFQ.\|.QCDK	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> TGM2_MOUSE @667
CATD_MOUSE	670	QCDK.\|.KLKS	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> TGM2_MOUSE @670

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)