Q76MZ3: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - PP2A subunit A isoform PR65-alpha - PP2A subunit A isoform R1-alpha
Gene names	Ppp2r1a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q76MZ3

9 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY
        70         80         90        100        110        120
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS
       130        140        150        160        170        180
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM
       190        200        210        220        230        240
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL
       250        260        270        280        290        300
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA
       310        320        330        340        350        360
AASHKVKEFC ENLSADCREN VIMTQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN
       370        380        390        400        410        420
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR
       430        440        450        460        470        480
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA
       490        500        510        520        530        540
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV
       550        560        570        580
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q76MZ3-2-unknown	MAAADG...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q76MZ3-2-unknown	MAAADG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q76MZ3-2-Acetylation	AAADGD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q76MZ3-2-Acetylation	AAADGD...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q76MZ3-96-unknown	LATVEE...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34035
Q76MZ3-97-unknown	ATVEET...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29218
Q76MZ3-97-unknown	ATVEET...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30655
Q76MZ3-136-unmodified	AGGDWF...	136			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q76MZ3-193-unknown	AKVLEL...	193		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000133334
Q76MZ3-212-unknown	LASDEQ...	212		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34036
Q76MZ3-300-unmodified	AAASHK...	300			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q76MZ3-306-unmodified	VKEFCE...	306			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPLESL	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34035
...PLESLA	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29218
...PLESLA	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30655
...PMFSNL	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34036
...PLFLAQ	371	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000133334
...VLSLA	589	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	95	LESL.\|.LATV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	96	ESLA.\|.ATVE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> 2AAA_MOUSE @96
CATE_MOUSE	96	ESLA.\|.ATVE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> 2AAA_MOUSE @96
MMP2_MOUSE	211	FSNL.\|.LASD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)