Q99KI0: Aconitate hydratase, mitochondrial

General Information

Protein names	- Aconitate hydratase, mitochondrial - Aconitase - 4.2.1.3 {ECO:0000250\|UniProtKB:P16276} - Citrate hydro-lyase
Gene names	Aco2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99KI0

7 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPS EYIRYDLLEK NINIVRKRLN
        70         80         90        100        110        120
RPLTLSEKIV YGHLDDPANQ EIERGKTYLR LRPDRVAMQD ATAQMAMLQF ISSGLPKVAV
       130        140        150        160        170        180
PSTIHCDHLI EAQVGGEKDL RRAKDINQEV YNFLATAGAK YGVGFWRPGS GIIHQIILEN
       190        200        210        220        230        240
YAYPGVLLIG TDSHTPNGGG LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG
       250        260        270        280        290        300
WTSPKDVILK VAGILTVKGG TGAIVEYHGP GVDSISCTGM ATICNMGAEI GATTSVFPYN
       310        320        330        340        350        360
HRMKKYLSKT GRTDIANLAE EFKDHLVPDP GCQYDQVIEI NLNELKPHIN GPFTPDLAHP
       370        380        390        400        410        420
VADVGTVAEK EGWPLDIRVG LIGSCTNSSY EDMGRSAAVA KQALAHGLKC KSQFTITPGS
       430        440        450        460        470        480
EQIRATIERD GYAQILRDVG GIVLANACGP CIGQWDRKDI KKGEKNTIVT SYNRNFTGRN
       490        500        510        520        530        540
DANPETHAFV TSPEIVTALA IAGTLKFNPE TDFLTGKDGK KFKLEAPDAD ELPRSDFDPG
       550        560        570        580        590        600
QDTYQHPPKD SSGQRVDVSP TSQRLQLLEP FDKWDGKDLE DLQILIKVKG KCTTDHISAA
       610        620        630        640        650        660
GPWLKFRGHL DNISNNLLIG AINIENGKAN SVRNAVTQEF GPVPDTARYY KKHGIRWVVI
       670        680        690        700        710        720
GDENYGEGSS REHAALEPRH LGGRAIITKS FARIHETNLK KQGLLPLTFA DPSDYNKIHP
       730        740        750        760        770        780
VDKLTIQGLK DFAPGKPLKC VIKHPNGTQE TILLNHTFNE TQIEWFRAGS ALNRMKELQQ

Isoforms

Sequence View

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99KI0-28-unknown	QRAKVA...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99KI0-28-unknown	QRAKVA...	28	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q99KI0-48-unknown	LEKNIN...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29306
Q99KI0-48-unknown	LEKNIN...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30961
Q99KI0-49-unknown	EKNINI...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30962
Q99KI0-66-unknown	SEKIVY...	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30963
Q99KI0-132-unknown	AQVGGE...	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30964
Q99KI0-232-unknown	VKLTGS...	232	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q99KI0-621-unknown	AINIEN...	621	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30965

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IRYDLL	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29306
...IRYDLL	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30961
...RYDLLE	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30962
...RPLTLS	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30963
...DHLIEA	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30964
...NLLIGA	620	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30965
...KELQQ	780	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATD_MOUSE	47	YDLL.\|.LEKN	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> ACON_MOUSE @47
CATE_MOUSE	47	YDLL.\|.LEKN	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ACON_MOUSE @47
CATE_MOUSE	48	DLLE.\|.EKNI	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ACON_MOUSE @48
CATE_MOUSE	65	LTLS.\|.SEKI	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ACON_MOUSE @65
CATE_MOUSE	131	LIEA.\|.AQVG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ACON_MOUSE @131
CATE_MOUSE	620	LIGA.\|.AINI	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> ACON_MOUSE @620

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)