Q3THE2: Myosin regulatory light chain 12B

General Information

Protein names	- Myosin regulatory light chain 12B - Myosin regulatory light chain 2-B, smooth muscle isoform - Myosin regulatory light chain 20 kDa - MLC20 - Myosin regulatory light chain MRLC2
Gene names	Myl12b
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q3THE2

4 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS
        70         80         90        100        110        120
LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE
       130        140        150        160        170
DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q3THE2-1-unknown	MSSKKA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q3THE2-24-unknown	AMFDQS...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30418
Q3THE2-34-unknown	FKEAFN...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29119
Q3THE2-34-unknown	FKEAFN...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30419
Q3THE2-150-unknown	KKGNFN...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33903

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TSNVFA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30418
...SQIQEF	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29119
...SQIQEF	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30419
...EAPIDK	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33903
...KDKDD	172	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	23	NVFA.\|.AMFD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ML12B_MOUSE @23
CATD_MOUSE	33	IQEF.\|.FKEA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ML12B_MOUSE @33
CATE_MOUSE	33	IQEF.\|.FKEA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ML12B_MOUSE @33
MMP2_MOUSE	149	PIDK.\|.KKGN	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)