P50580: Proliferation-associated protein 2G4

General Information

Protein names	- Proliferation-associated protein 2G4 - IRES-specific cellular trans-acting factor 45 kDa - ITAF45 - Mpp1 - Proliferation-associated protein 1 - Protein p38-2G4
Gene names	Pa2g4
Organism	Mus musculus
Protease Family
Protease ID	M24.973
Chromosome location
UniProt ID	P50580

15 N-termini

14 C-termini

17 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET
        70         80         90        100        110        120
GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN
       130        140        150        160        170        180
VAHTFVIGVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT
       190        200        210        220        230        240
PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA
       250        260        270        280        290        300
GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE
       310        320        330        340        350        360
LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS
       370        380        390
SASRKTQKKK KKKASKTVEN ATSGETLEEN GAGD

Isoforms

- Isoform 2 of Proliferation-associated protein 2G4

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 14 C-termini - 17 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50580-2-unknown	MSGEDE...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P50580-2-unknown	MSGEDE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50580-2-Acetylation	SGEDEQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50580-2-Acetylation	SGEDEQ...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P50580-2-Acetylation	SGEDEQ...	2	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P50580-2-Acetylation	SGEDEQ...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P50580-17-unknown	VVTKYK...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30024
P50580-17-unknown	VVTKYK...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28904
P50580-23-unknown	MGGDIA...	23		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P50580-129-unknown	VAQGTQ...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28905
P50580-223-unknown	VYAVDV...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33593
P50580-225-unknown	AVDVLV...	225		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30025
P50580-226-unknown	VDVLVS...	226		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30026
P50580-228-unknown	VLVSSG...	228		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30027
P50580-228-unknown	VLVSSG...	228		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32350
P50580-230-unknown	VSSGEG...	230		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30028
P50580-230-unknown	VSSGEG...	230		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28906
P50580-283-unknown	FEDEKK...	283		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30029
P50580-283-unknown	FEDEKK...	283		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28907
P50580-342-unknown	LYKSEM...	342		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32351
P50580-347-unknown	MEVQDA...	347		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33594
P50580-348-unknown	EVQDAE...	348		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30030
P50580-348-unknown	EVQDAE...	348		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28908
P50580-351-unknown	DAELKA...	351		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28909

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IAEDLV	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30024
...IAEDLV	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28904
...TFVIGV	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28905
...FEVHEV	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33593
...VHEVYA	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30025
...HEVYAV	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30026
...VYAVDV	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30027
...VYAVDV	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32350
...AVDVLV	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30028
...AVDVLV	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28906
...FTLRAF	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30029
...FTLRAF	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28907
...LYEKEG	312	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000114434
...PFEPDL	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32351
...LYKSEM	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33594
...YKSEME	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30030
...YKSEME	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28908
...EMEVQD	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28909
...NGAGD	394	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	16	EDLV.\|.VVTK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @16
CATD_MOUSE	16	EDLV.\|.VVTK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @16
CATD_MOUSE	128	VIGV.\|.VAQG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @128
MMP2_MOUSE	222	VHEV.\|.VYAV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	224	EVYA.\|.AVDV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @224
CATE_MOUSE	225	VYAV.\|.VDVL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @225
CATE_MOUSE	227	AVDV.\|.VLVS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @227
GRAB_MOUSE	227	AVDV.\|.VLVS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	229	DVLV.\|.VSSG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @229
CATD_MOUSE	229	DVLV.\|.VSSG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @229
CATE_MOUSE	282	LRAF.\|.FEDE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @282
CATD_MOUSE	282	LRAF.\|.FEDE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @282
GRAB_MOUSE	341	EPDL.\|.LYKS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	346	KSEM.\|.MEVQ	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	347	SEME.\|.EVQD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PA2G4_MOUSE @347
CATD_MOUSE	347	SEME.\|.EVQD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @347
CATD_MOUSE	350	EVQD.\|.DAEL	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PA2G4_MOUSE @350

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)