Q9CVD2: Ataxin-3

General Information

Protein names	- Ataxin-3 - 3.4.19.12 - Machado-Joseph disease protein 1 homolog
Gene names	Atxn3
Organism	Mus musculus
Protease Family
Protease ID	C86.001
Chromosome location
UniProt ID	Q9CVD2

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERLRMAE GGVTSEDYRT
        70         80         90        100        110        120
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW
       130        140        150        160        170        180
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM
       190        200        210        220        230        240
IKVQQMHRPK LIGEELAHLK EQSALKADLE RVLEAADGSG IFDEDEDDLQ RALAISRQEI
       250        260        270        280        290        300
DMEDEEADLR RAIQLSMQGS SRSMCENSPQ TSSPDLSSEE LRRRREAYFE KQQQQQQEVD
       310        320        330        340        350
RPGPLSYPRE RPTTSSGGRR SDQGGDAVSE EDMLRAAVTM SLETAKDNLK AERKK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9CVD2-1-unknown	MESIFH...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9CVD2-4-unknown	IFHEKQ...	4	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000124419
Q9CVD2-341-unknown	SLETAK...	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31031
Q9CVD2-343-unknown	ETAKDN...	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29338

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AYFEKQ	291	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000125378
...AYFEKQ	291	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000124419
...AAVTMS	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31031
...VTMSLE	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29338
...AERKK	355	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	340	VTMS.\|.SLET	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ATX3_MOUSE @340
CATD_MOUSE	342	MSLE.\|.ETAK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ATX3_MOUSE @342

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)