P70677: Caspase-3
Protein names | - Caspase-3 - CASP-3 - 3.4.22.56 - Apopain - Cysteine protease CPP32 - CPP-32 - LICE - Protein Yama - SREBP cleavage activity 1 - SCA-1 - Caspase-3 subunit p17 - Caspase-3 subunit p12 |
---|---|
Gene names | Casp3 |
Organism | Mus musculus |
Protease Family | C14.003 |
Protease ID | C14.003 |
Chromosome location | |
UniProt ID | P70677 |
3
N-termini
3
C-termini
3
Cleavages
101
Substrates
Sequence
10 20 30 40 50 60
MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG
70 80 90 100 110 120
MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS
130 140 150 160 170 180
HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE
190 200 210 220 230 240
EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN
250 260 270
RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 3 Cleavages - 101 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P70677-29-unknown | SGIYLD... | 29 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P70677-29-unknown | SGIYLD... | 29 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P70677-79-unknown | MGLKYQ... | 79 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29080 | |||
P70677-176-unknown | SGTDEE... | 176 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P70677-176-unknown | SGTDEE... | 176 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28528 | |||
P70677-176-unknown | SGTDEE... | 176 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32397 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LRETFM | 78 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29080 | |||
...GIETDS | 175 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GIETDS | 175 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28528 | |||
...GIETDS | 175 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32397 | |||
...LYFYH | 277 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATD_MOUSE | 78 | ETFM.|.MGLK | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> CASP3_MOUSE @78 | ||
CASP4_MOUSE | 175 | ETDS.|.SGTD | inferred from experiment | unknown | MEROPS | Yuan J | Kang SJ et al.:Dual role of caspase-11 in medi... (C14.012) | 10791975, |
GRAB_MOUSE | 175 | ETDS.|.SGTD | inferred from experiment | unknown | MEROPS | Rosen A | Casciola-Rosen L et al.:Mouse and human granzyme B have... (S01.010) | 17179148, |