P58252: Elongation factor 2

General Information

Protein names	- Elongation factor 2 - EF-2
Gene names	Eef2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P58252

26 N-termini

18 C-termini

19 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVNFTVDQIR AIMDKKANIR NMSVIAHVDH GKSTLTDSLV CKAGIIASAR AGETRFTDTR
        70         80         90        100        110        120
KDEQERCITI KSTAISLFYE LSENDLNFIK QSKDGSGFLI NLIDSPGHVD FSSEVTAALR
       130        140        150        160        170        180
VTDGALVVVD CVSGVCVQTE TVLRQAIAER IKPVLMMNKM DRALLELQLE PEELYQTFQR
       190        200        210        220        230        240
IVENVNVIIS TYGEGESGPM GNIMIDPVLG TVGFGSGLHG WAFTLKQFAE MYVAKFAAKG
       250        260        270        280        290        300
EGQLSAAERA KKVEDMMKKL WGDRYFDPAN GKFSKSANSP DGKKLPRTFC QLILDPIFKV
       310        320        330        340        350        360
FDAIMNFRKE ETAKLIEKLD IKLDSEDKDK EGKPLLKAVM RRWLPAGDAL LQMITIHLPS
       370        380        390        400        410        420
PVTAQKYRCE LLYEGPPDDE AAMGIKSCDP KGPLMMYISK MVPTSDKGRF YAFGRVFSGV
       430        440        450        460        470        480
VSTGLKVRIM GPNYTPGKKE DLYLKPIQRT ILMMGRYVEP IEDVPCGNIV GLVGVDQFLV
       490        500        510        520        530        540
KTGTITTFEH AHNMRVMKFS VSPVVRVAVE AKNPADLPKL VEGLKRLAKS DPMVQCIIEE
       550        560        570        580        590        600
SGEHIIAGAG ELHLEICLKD LEEDHACIPI KKSDPVVSYR ETVSEESNVL CLSKSPNKHN
       610        620        630        640        650        660
RLYMKARPFP DGLAEDIDKG EVSARQELKA RARYLAEKYE WDVAEARKIW CFGPDGTGPN
       670        680        690        700        710        720
ILTDITKGVQ YLNEIKDSVV AGFQWATKEG ALCEENMRGV RFDVHDVTLH ADAIHRGGGQ
       730        740        750        760        770        780
IIPTARRCLY ASVLTAQPRL MEPIYLVEIQ CPEQVVGGIY GVLNRKRGHV FEESQVAGTP
       790        800        810        820        830        840
MFVVKAYLPV NESFGFTADL RSNTGGQAFP QCVFDHWQIL PGDPFDNSSR PSQVVAETRK
       850
RKGLKEGIPA LDNFLDKL

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 18 C-termini - 19 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P58252-2-unmodified	VNFTVD...	2		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P58252-2-unmodified	VNFTVD...	2		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P58252-2-unknown	VNFTVD...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P58252-5-unknown	TVDQIR...	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28945
P58252-38-unknown	SLVCKA...	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28477
P58252-38-unknown	SLVCKA...	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28555
P58252-40-unknown	VCKAGI...	40	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30111
P58252-42-unknown	KAGIIA...	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30112
P58252-104-unknown	DSPGHV...	104	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P58252-112-unknown	SSEVTA...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30113
P58252-193-unknown	GEGESG...	193	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P58252-233-unknown	VAKFAA...	233	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28946
P58252-262-unknown	GDRYFD...	262	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P58252-396-unknown	MYISKM...	396	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33641
P58252-398-unknown	ISKMVP...	398	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28947
P58252-418-unknown	SGVVST...	418	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28948
P58252-606-unknown	ARPFPD...	606	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33642
P58252-613-unknown	LAEDID...	613	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33643
P58252-614-unknown	AEDIDK...	614	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30114
P58252-616-unknown	DIDKGE...	616	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30115
P58252-617-unknown	IDKGEV...	617	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30116
P58252-635-unknown	LAEKYE...	635	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33644
P58252-638-unknown	KYEWDV...	638	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33645
P58252-683-unknown	FQWATK...	683	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33646
P58252-717-unmodified	GGGQII...	717		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P58252-729-unmodified	LYASVL...	729		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P58252-731-unknown	ASVLTA...	731	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30117
P58252-813-unmodified	VFDHWQ...	813		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...STLTDS	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28477
...STLTDS	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28555
...LTDSLV	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30111
...DSLVCK	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30112
...GHVDFS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30113
...FAEMYV	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28946
...KGPLMM	395	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33641
...PLMMYI	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28947
...FGRVFS	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28948
...RLYMKA	605	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33642
...PFPDGL	612	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33643
...FPDGLA	613	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30114
...DGLAED	615	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30115
...GLAEDI	616	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30116
...ARARYL	634	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33644
...RYLAEK	637	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33645
...SVVAGF	682	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33646
...RRCLYA	730	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30117
...FLDKL	858	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	4	VNFT.\|.TVDQ	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> EF2_MOUSE @4
CASP3_MOUSE	37	LTDS.\|.SLVC	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	37	LTDS.\|.SLVC	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CATE_MOUSE	39	DSLV.\|.VCKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @39
CATE_MOUSE	41	LVCK.\|.KAGI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @41
CATE_MOUSE	111	VDFS.\|.SSEV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @111
CATD_MOUSE	232	EMYV.\|.VAKF	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> EF2_MOUSE @232
MMP2_MOUSE	395	PLMM.\|.MYIS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	397	MMYI.\|.ISKM	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> EF2_MOUSE @397
CATD_MOUSE	417	RVFS.\|.SGVV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> EF2_MOUSE @417
MMP2_MOUSE	605	YMKA.\|.ARPF	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> EF2_MOUSE @605
MMP2_MOUSE	612	PDGL.\|.LAED	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	613	DGLA.\|.AEDI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @613
CATE_MOUSE	615	LAED.\|.DIDK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @615
CATE_MOUSE	616	AEDI.\|.IDKG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @616
MMP2_MOUSE	634	ARYL.\|.LAEK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	637	LAEK.\|.KYEW	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	682	VAGF.\|.FQWA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	730	CLYA.\|.ASVL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EF2_MOUSE @730

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)