P49710: Hematopoietic lineage cell-specific protein

General Information

Protein names	- Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1 - LckBP1
Gene names	Hcls1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P49710

7 N-termini

7 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK
        70         80         90        100        110        120
VSEEHDILKK KELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVADVEKH SSQTDAARGF
       130        140        150        160        170        180
GGKYGVERDR ADKSAVGFDY KGEVEKHASQ KDYSHGFGGR YGVEKDKRDK AALGYDYKGE
       190        200        210        220        230        240
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA
       250        260        270        280        290        300
KFESLAEEKR KREEEEKAQQ MARQQQERKA VVKMSREVQQ PSMPVEEPAA PAQLPKKISS
       310        320        330        340        350        360
EVWPPAESHL PPESQPVRSR REYPVPSLPT RQSPLQNHLE DNEEPPALPP RTPEGLQVVE
       370        380        390        400        410        420
EPVYEAAPEL EPEPEPDYEP EPETEPDYED VGELDRQDED AEGDYEDVLE PEDTPSLSYQ
       430        440        450        460        470        480
AGPSAGAGGA GISAIALYDY QGEGSDELSF DPDDIITDIE MVDEGWWRGQ CRGHFGLFPA

NYVKLL

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49710-1-unknown	MWKSVV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49710-28-unknown	VNDISE...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30015
P49710-156-unknown	GFGGRY...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28357
P49710-190-unknown	YAKGFG...	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28467
P49710-190-unknown	YAKGFG...	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28547
P49710-213-unknown	NEMEAP...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30016
P49710-215-unknown	MEAPTT...	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30017
P49710-388-unknown	YEDVGE...	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32348

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TDPDFV	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30015
...KDYSHG	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28357
...ESQRDY	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28467
...ESQRDY	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28547
...SAVGFN	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30016
...VGFNEM	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30017
...ETEPDY	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32348
...YVKLL	486	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	27	PDFV.\|.VNDI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HCLS1_MOUSE @27
CASP1_MOUSE	155	YSHG.\|.GFGG	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP3_MOUSE	189	QRDY.\|.YAKG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	189	QRDY.\|.YAKG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CATE_MOUSE	212	VGFN.\|.NEME	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HCLS1_MOUSE @212
CATE_MOUSE	214	FNEM.\|.MEAP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HCLS1_MOUSE @214
GRAB_MOUSE	387	EPDY.\|.YEDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)