Q921F2: TAR DNA-binding protein 43

General Information

Protein names	- TAR DNA-binding protein 43 - TDP-43
Gene names	Tardbp
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q921F2

4 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI
        70         80         90        100        110        120
LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL
       130        140        150        160        170        180
KDYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS
       190        200        210        220        230        240
KQSPDEPLRS RKVFVGRCTE DMTAEELQQF FCQYGEVVDV FIPKPFRAFA FVTFADDKVA
       250        260        270        280        290        300
QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG
       310        320        330        340        350        360
NNQGGNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQSQGSMQ
       370        380        390        400        410
REPNQAFGSG NNSYSGSNSG APLGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q921F2-1-unknown	MSEYIR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q921F2-28-unknown	LSTVTA...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29283
Q921F2-71-unknown	LVYVVN...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34148
Q921F2-90-unknown	ASSAVK...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28519
Q921F2-90-unknown	ASSAVK...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28598

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DGTVLL	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29283
...AGWGNL	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34148
...MDETDA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28519
...MDETDA	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28598
...SGWGM	414	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	27	TVLL.\|.LSTV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> TADBP_MOUSE @27
MMP2_MOUSE	70	WGNL.\|.LVYV	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TADBP_MOUSE @70
CASP3_MOUSE	89	ETDA.\|.ASSA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	89	ETDA.\|.ASSA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)