P08113: Endoplasmin

General Information

Protein names	- Endoplasmin - 94 kDa glucose-regulated protein - GRP-94 - Endoplasmic reticulum resident protein 99 {ECO:0000303\|PubMed:3036833} - ERp99 {ECO:0000303\|PubMed:3036833} - Heat shock protein 90 kDa beta member 1 - Polymorphic tumor rejection antigen 1 - Tumor rejection antigen gp96
Gene names	Hsp90b1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P08113

22 N-termini

16 C-termini

20 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRVLWVLGLC CVLLTFGFVR ADDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG
        70         80         90        100        110        120
LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL
       130        140        150        160        170        180
TDENALAGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE
       190        200        210        220        230        240
AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT
       250        260        270        280        290        300
LGRGTTITLV LKEEASDYLE LDTIKNLVRK YSQFINFPIY VWSSKTETVE EPLEEDEAAK
       310        320        330        340        350        360
EEKEESDDEA AVEEEEEEKK PKTKKVEKTV WDWELMNDIK PIWQRPSKEV EEDEYKAFYK
       370        380        390        400        410        420
SFSKESDDPM AYIHFTAEGE VTFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD
       430        440        450        460        470        480
DFHDMMPKYL NFVKGVVDSD DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADEKY
       490        500        510        520        530        540
NDTFWKEFGT NIKLGVIEDH SNRTRLAKLL RFQSSHHSTD ITSLDQYVER MKEKQDKIYF
       550        560        570        580        590        600
MAGSSRKEAE SSPFVERLLK KGYEVIYLTE PVDEYCIQAL PEFDGKRFQN VAKEGVKFDE
       610        620        630        640        650        660
SEKTKESREA TEKEFEPLLN WMKDKALKDK IEKAVVSQRL TESPCALVAS QYGWSGNMER
       670        680        690        700        710        720
IMKAQAYQTG KDISTNYYAS QKKTFEINPR HPLIRDMLRR IKEDEDDKTV MDLAVVLFET
       730        740        750        760        770        780
ATLRSGYLLP DTKAYGDRIE RMLRLSLNID PEAQVEEEPE EEPEDTSEDA EDSEQDEGEE
       790        800
MDAGTEEEEE ETEKESTEKD EL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

22 N-termini - 16 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08113-22-unmodified	DDEVDV...	22			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P08113-22-unknown	DDEVDV...	22		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08113-22-unknown	DDEVDV...	22			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P08113-27-unknown	VDGTVE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28433
P08113-27-unknown	VDGTVE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28534
P08113-27-unknown	VDGTVE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28348
P08113-29-unknown	GTVEED...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28434
P08113-29-unknown	GTVEED...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32300
P08113-29-unknown	GTVEED...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28535
P08113-56-unknown	IQLDGL...	56		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29651
P08113-60-unknown	GLNASQ...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28435
P08113-60-unknown	GLNASQ...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28536
P08113-103-unknown	ELISNA...	103		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P08113-103-acetylation	ELISNA...	103	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P08113-104-unknown	LISNAS...	104		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33264
P08113-105-unknown	ISNASD...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33265
P08113-106-unknown	SNASDA...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33266
P08113-108-unknown	ASDALD...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33267
P08113-108-unknown	ASDALD...	108		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08113-108-unknown	ASDALD...	108		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P08113-122-unknown	DENALA...	122		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P08113-139-unmodified	DKEKNL...	139			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P08113-140-unknown	KEKNLL...	140		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P08113-286-unknown	TETVEE...	286		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000122710
P08113-433-unknown	VKGVVD...	433		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29652
P08113-539-unknown	YFMAGS...	539		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29653
P08113-575-unknown	YCIQAL...	575		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29654
P08113-667-unknown	YQTGKD...	667		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33268
P08113-678-unknown	YASQKK...	678		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29655
P08113-678-unknown	YASQKK...	678		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33269
P08113-681-unknown	QKKTFE...	681		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33270

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDEVDV	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28433
...DDEVDV	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28534
...DDEVDV	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28348
...EVDVDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28434
...EVDVDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32300
...EVDVDG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28535
...REEEAI	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29651
...AIQLDG	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28435
...AIQLDG	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28536
...IFLREL	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33264
...FLRELI	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33265
...LRELIS	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33266
...ELISNA	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33267
...KYLNFV	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29652
...KQDKIY	538	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29653
...EPVDEY	574	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29654
...MKAQAY	666	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33268
...ISTNYY	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29655
...ISTNYY	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33269
...NYYASQ	680	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33270
...LIRDML	697	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122710
...EKDEL	802	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	26	EVDV.\|.VDGT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	26	EVDV.\|.VDGT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	26	EVDV.\|.VDGT	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP3_MOUSE	28	DVDG.\|.GTVE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_MOUSE	28	DVDG.\|.GTVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_MOUSE	28	DVDG.\|.GTVE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CATE_MOUSE	55	EEAI.\|.IQLD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ENPL_MOUSE @55
CASP3_MOUSE	59	QLDG.\|.GLNA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	59	QLDG.\|.GLNA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	103	LREL.\|.LISN	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	104	RELI.\|.ISNA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	105	ELIS.\|.SNAS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	107	ISNA.\|.ASDA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	432	LNFV.\|.VKGV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ENPL_MOUSE @432
CATE_MOUSE	538	DKIY.\|.YFMA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ENPL_MOUSE @538
CATE_MOUSE	574	VDEY.\|.YCIQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ENPL_MOUSE @574
MMP2_MOUSE	666	AQAY.\|.YQTG	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> ENPL_MOUSE @666
CATE_MOUSE	677	TNYY.\|.YASQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ENPL_MOUSE @677
MMP2_MOUSE	677	TNYY.\|.YASQ	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	680	YASQ.\|.QKKT	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> ENPL_MOUSE @680

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)