P26369: Splicing factor U2AF 65 kDa subunit

General Information

Protein names	- Splicing factor U2AF 65 kDa subunit - U2 auxiliary factor 65 kDa subunit - U2 snRNP auxiliary factor large subunit
Gene names	U2af2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P26369

6 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD QRSASRDRRR
        70         80         90        100        110        120
RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE HITPMQYKAM QAAGQIPATA
       130        140        150        160        170        180
LLPTMTPDGL AVTPTPVPVV GSQMTRQARR LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ
       190        200        210        220        230        240
APGNPVLAVQ INQDKNFAFL EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE
       250        260        270        280        290        300
NPSVYVPGVV STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK
       310        320        330        340        350        360
GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLVSLPST INQTPVTLQV
       370        380        390        400        410        420
PGLMSSQVQM GGHPTEVLCL MNMVLPEELL DDEEYEEIVE DVRDECSKYG LVKSIEIPRP
       430        440        450        460        470
VDGVEVPGCG KIFVEFTSVF DCQKAMQGLT GRKFANRVVV TKYCDPDSYH RRDFW

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26369-2-unknown	MSDFDE...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P26369-2-unknown	MSDFDE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26369-2-Acetylation	SDFDEF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26369-2-Acetylation	SDFDEF...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P26369-68-unmodified	GAKEEH...	68			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P26369-129-unknown	GLAVTP...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28458
P26369-129-unknown	GLAVTP...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32332
P26369-129-unknown	GLAVTP...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28542
P26369-133-unknown	TPTPVP...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28354
P26369-165-unknown	MMDFFN...	165		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000131458

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TMTPDG	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28458
...TMTPDG	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32332
...TMTPDG	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28542
...DGLAVT	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28354
...RRDFW	475	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	128	TPDG.\|.GLAV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_MOUSE	128	TPDG.\|.GLAV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_MOUSE	128	TPDG.\|.GLAV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	132	LAVT.\|.TPTP	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)