Q8VEK3: Heterogeneous nuclear ribonucleoprotein U {ECO:0000312|MGI:MGI:1858195}

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein U {ECO:0000312\|MGI:MGI:1858195} - hnRNP U {ECO:0000303\|Ref.5} - Scaffold-attachment factor A {ECO:0000303\|PubMed:18332112} - SAF-A {ECO:0000303\|PubMed:18332112}
Gene names	Hnrnpu
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8VEK3

9 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KADLMDRLQA ALDNEAGGRP AMEPGNGSLD
        70         80         90        100        110        120
LGGDAAGRSG AGLEQEAAAG AEDDEEEEGI AALDGDQMEL GEENGAAGAA DAGAMEEEEA
       130        140        150        160        170        180
ASEDENGDDQ GFQEGEDELG DEEEGAGDEN GHGEQQSQPP AAAAQQQPSQ QRGAGKEAAG
       190        200        210        220        230        240
KSSGPTSLFA VTVAPPGARQ GQQQAGGDGK TEQKGGDKKR GVKRPREDHG RGYFEYIEEN
       250        260        270        280        290        300
KYSRAKSPQP PVEEEDEHFD DTVVCLDTYN CDLHFKISRD RLSASSLTME SFAFLWAGGR
       310        320        330        340        350        360
ASYGVSKGKV CFEMKVTEKI PVRHLYTKDI DIHEVRIGWS LTTSGMLLGE EEFSYGYSLK
       370        380        390        400        410        420
GIKTCNCETE DYGEKFDEND VITCFANFET DEVELSYAKN GQDLGVAFKI SKEVLADRPL
       430        440        450        460        470        480
FPHVLCHNCA VEFNFGQKEK PYFPIPEDCT FIQNVPLEDR VRGPKGPEEK KDCEVVMMIG
       490        500        510        520        530        540
LPGAGKTTWV TKHAAENPGK YNILGTNTIM DKMMVAGFKK QMADTGKLNT LLQRAPQCLG
       550        560        570        580        590        600
KFIEIAARKK RNFILDQTNV SAAAQRRKMC LFAGFQRKAV VVCPKDEDYK QRTQKKAEVE
       610        620        630        640        650        660
GKDLPEHAVL KMKGNFTLPE VAECFDEITY VELQKEEAQK LLEQYKEESK KALPPEKKQN
       670        680        690        700        710        720
TGSKKSNKNK SGKNQFNRGG GHRGRGGFNM RGGNFRGGAP GNRGGYNRRG NMPQRGGGGG
       730        740        750        760        770        780
SGGIGYPYPR GPVFPGRGGY SNRGNYNRGG MPNRGNYNQN FRGRGNNRGY KNQSQGYNQW
       790        800
QQGQFWGQKP WSQHYHQGYY

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein U

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8VEK3-2-unknown	MSSSPV...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q8VEK3-2-unknown	MSSSPV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8VEK3-2-Acetylation	SSSPVN...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8VEK3-2-Acetylation	SSSPVN...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q8VEK3-57-unknown	GSLDLG...	57			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q8VEK3-188-unknown	LFAVTV...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34126
Q8VEK3-189-unknown	FAVTVA...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34127
Q8VEK3-209-unknown	GKTEQK...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28516
Q8VEK3-209-unknown	GKTEQK...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28593
Q8VEK3-232-unknown	GYFEYI...	232			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q8VEK3-325-unknown	LYTKDI...	325		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34128
Q8VEK3-525-unknown	TGKLNT...	525		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32529

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGPTSL	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34126
...GPTSLF	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34127
...QAGGDG	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28516
...QAGGDG	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28593
...IPVRHL	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34128
...KQMADT	524	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32529
...HQGYY	800	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	187	PTSL.\|.LFAV	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	188	TSLF.\|.FAVT	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CASP3_MOUSE	208	GGDG.\|.GKTE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	208	GGDG.\|.GKTE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	324	VRHL.\|.LYTK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
GRAB_MOUSE	524	MADT.\|.TGKL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)