P63260: Actin, cytoplasmic 2

General Information

Protein names	- Actin, cytoplasmic 2 - Gamma-actin - Actin, cytoplasmic 2, N-terminally processed
Gene names	Actg1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P63260

24 N-termini

22 C-termini

35 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS
        70         80         90        100        110        120
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT
       130        140        150        160        170        180
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL
       190        200        210        220        230        240
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY
       250        260        270        280        290        300
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
       310        320        330        340        350        360
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ
       370
EYDESGPSIV HRKCF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

24 N-termini - 22 C-termini - 35 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P63260-1-Acetylation	MEEEIA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63260-2-Acetylation	EEEIAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63260-2-Acetylation	EEEIAA...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P63260-5-unknown	IAALVI...	5		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30252
P63260-7-unknown	ALVIDN...	7		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30253
P63260-8-unknown	LVIDNG...	8		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30254
P63260-8-unknown	LVIDNG...	8		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29040
P63260-8-unknown	LVIDNG...	8		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33752
P63260-9-unknown	VIDNGS...	9		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30255
P63260-9-unknown	VIDNGS...	9		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29041
P63260-12-unknown	NGSGMC...	12		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28486
P63260-12-unknown	NGSGMC...	12		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32377
P63260-12-unknown	NGSGMC...	12		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28565
P63260-12-unknown	NGSGMC...	12		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28365
P63260-45-unknown	VGMGQK...	45		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30256
P63260-54-unknown	VGDEAQ...	54		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30257
P63260-105-unknown	LTEAPL...	105		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30258
P63260-105-unknown	LTEAPL...	105		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29042
P63260-137-unknown	QAVLSL...	137		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30259
P63260-140-unknown	LSLYAS...	140		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30260
P63260-190-unknown	MKILTE...	190		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30261
P63260-223-unknown	FEQEMA...	223		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32378
P63260-228-unknown	ATAASS...	228		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29043
P63260-245-unknown	GQVITI...	245		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28487
P63260-245-unknown	GQVITI...	245		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32379
P63260-245-unknown	GQVITI...	245		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28566
P63260-245-unknown	GQVITI...	245		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28366
P63260-246-unknown	QVITIG...	246		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000087043
P63260-269-unknown	MESCGI...	269		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29044
P63260-280-unknown	NSIMKC...	280		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30262
P63260-280-unknown	NSIMKC...	280		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29045
P63260-294-unknown	YANTVL...	294		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30263
P63260-294-unknown	YANTVL...	294		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29046
P63260-297-unknown	TVLSGG...	297		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30264
P63260-298-unknown	VLSGGT...	298		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30265
P63260-300-unknown	SGGTTM...	300		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30266
P63260-300-unknown	SGGTTM...	300		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29047
P63260-357-unknown	ISKQEY...	357		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30267
P63260-357-unknown	ISKQEY...	357		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29048

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EEEIAA	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30253
...EEIAAL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30254
...EEIAAL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29040
...EEIAAL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33752
...EIAALV	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30255
...EIAALV	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29041
...ALVIDN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28486
...ALVIDN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32377
...ALVIDN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28565
...ALVIDN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28365
...HQGVMV	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30256
...QKDSYV	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30257
...EHPVLL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30258
...EHPVLL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29042
...MYVAIQ	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30259
...AIQAVL	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30260
...LTDYLM	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30261
...EIVRDI	211	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000134296
...YVALDF	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32378
...FEQEMA	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29043
...YELPDG	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28487
...YELPDG	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32379
...YELPDG	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28566
...YELPDG	244	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28366
...PSFLGM	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29044
...HETTFN	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30262
...HETTFN	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29045
...IRKDLY	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30263
...IRKDLY	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29046
...DLYANT	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30264
...LYANTV	297	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30265
...ANTVLS	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30266
...ANTVLS	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29047
...FQQMWI	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30267
...FQQMWI	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29048
...HRKCF	375	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	4	EEEI.\|.IAAL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @4
CATE_MOUSE	6	EIAA.\|.ALVI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @6
CATE_MOUSE	7	IAAL.\|.LVID	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @7
CATD_MOUSE	7	IAAL.\|.LVID	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACTG_MOUSE @7
MMP2_MOUSE	7	IAAL.\|.LVID	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	8	AALV.\|.VIDN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @8
CATD_MOUSE	8	AALV.\|.VIDN	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACTG_MOUSE @8
CASP3_MOUSE	11	VIDN.\|.NGSG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_MOUSE	11	VIDN.\|.NGSG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_MOUSE	11	VIDN.\|.NGSG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	11	VIDN.\|.NGSG	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CATE_MOUSE	44	GVMV.\|.VGMG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @44
CATE_MOUSE	53	DSYV.\|.VGDE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @53
CATE_MOUSE	104	PVLL.\|.LTEA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @104
CATD_MOUSE	104	PVLL.\|.LTEA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACTG_MOUSE @104
CATE_MOUSE	136	VAIQ.\|.QAVL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @136
CATE_MOUSE	139	QAVL.\|.LSLY	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @139
CATE_MOUSE	189	DYLM.\|.MKIL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @189
GRAB_MOUSE	222	ALDF.\|.FEQE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATD_MOUSE	227	QEMA.\|.ATAA	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CASP3_MOUSE	244	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_MOUSE	244	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_MOUSE	244	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	244	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CATD_MOUSE	268	FLGM.\|.MESC	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	279	TTFN.\|.NSIM	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @279
CATD_MOUSE	279	TTFN.\|.NSIM	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	293	KDLY.\|.YANT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @293
CATD_MOUSE	293	KDLY.\|.YANT	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	296	YANT.\|.TVLS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @296
CATE_MOUSE	297	ANTV.\|.VLSG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @297
CATE_MOUSE	299	TVLS.\|.SGGT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @299
CATD_MOUSE	299	TVLS.\|.SGGT	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	356	QMWI.\|.ISKQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTG_MOUSE @356
CATD_MOUSE	356	QMWI.\|.ISKQ	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)