P62196: 26S proteasome regulatory subunit 8

General Information

Protein names	- 26S proteasome regulatory subunit 8 - 26S proteasome AAA-ATPase subunit RPT6 - Proteasome 26S subunit ATPase 5 - Proteasome subunit p45 - p45/SUG - mSUG1
Gene names	Psmc5
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P62196

7 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN ELNAKVRLLR
        70         80         90        100        110        120
EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD KNIDINDVTP NCRVALRNDS
       130        140        150        160        170        180
YTLHKILPNK VDPLVSLMMV EKVPDSTYEM IGGLDKQIKE IKEVIELPVK HPELFEALGI
       190        200        210        220        230        240
AQPKGVLLYG PPGTGKTLLA RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE
       250        260        270        280        290        300
HAPSIIFMDE IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI
       310        320        330        340        350        360
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK
       370        380        390        400
GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62196-2-unknown	MALDGP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62196-2-Acetylation	ALDGPE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62196-5-unmodified	GPEQME...	5			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P62196-5-unknown	GPEQME...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28480
P62196-5-unknown	GPEQME...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28558
P62196-5-unknown	GPEQME...	5			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P62196-12-unknown	EEGKAG...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30169
P62196-176-unknown	EALGIA...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30170
P62196-185-unmodified	GVLLYG...	185			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EQMELE	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30169
...HPELFE	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30170
...KKLWK	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	4	ALDG.\|.GPEQ	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	4	ALDG.\|.GPEQ	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CATE_MOUSE	11	MELE.\|.EEGK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PRS8_MOUSE @11
CATE_MOUSE	175	ELFE.\|.EALG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PRS8_MOUSE @175

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)