O54786: DNA fragmentation factor subunit alpha

General Information

Protein names	- DNA fragmentation factor subunit alpha - DNA fragmentation factor 45 kDa subunit - DFF-45 - Inhibitor of CAD - ICAD
Gene names	Dffa
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O54786

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELSRGASAP DPDDVRPLKP CLLRRNHSRD QHGVAASSLE ELRSKACELL AIDKSLTPIT
        70         80         90        100        110        120
LVLAEDGTIV DDDDYFLCLP SNTKFVALAC NEKWIYNDSD GGTAWVSQES FEADEPDSRA
       130        140        150        160        170        180
GVKWKNVARQ LKEDLSSIIL LSEEDLQALI DIPCAELAQE LCQSCATVQG LQSTLQQVLD
       190        200        210        220        230        240
QREEARQSKQ LLELYLQALE KEGNILSNQK ESKAALSEEL DAVDTGVGRE MASEVLLRSQ
       250        260        270        280        290        300
ILTTLKEKPA PELSLSSQDL ESVSKEDPKA LAVALSWDIR KAETVQQACT TELALRLQQV
       310        320        330
QSLHSLRNLS ARRSPLPGEP QRPKRAKRDS S

Isoforms

- Isoform ICAD-S of DNA fragmentation factor subunit alpha

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O54786-1-Acetylation	MELSRG...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O54786-1-Acetylation	MELSRG...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96999
O54786-1-unknown	MELSRG...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt72657
O54786-118-unknown	SRAGVK...	118		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28428
O54786-118-unknown	SRAGVK...	118		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143344
O54786-225-unknown	TGVGRE...	225		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28430
O54786-225-unknown	TGVGRE...	225		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147536

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADEPDS	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28428
...ADEPDS	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126575
...LDAVDT	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28430
...LDAVDT	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130887
...KRDSS	331	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	117	EPDS.\|.SRAG	inferred from experiment	unknown	MEROPS	Nagata S	Sakahira H et al.:Cleavage of CAD inhibitor in CA... (C14.003)	9422513,
CASP3_MOUSE	224	AVDT.\|.TGVG	inferred from experiment	unknown	MEROPS	Nagata S	Sakahira H et al.:Cleavage of CAD inhibitor in CA... (C14.003)	9422513,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)