P16675: Lysosomal protective protein
Protein names | - Lysosomal protective protein - 3.4.16.5 - Carboxypeptidase C - Carboxypeptidase L - Cathepsin A - Protective protein cathepsin A - PPCA - Protective protein for beta-galactosidase - Lysosomal protective protein 32 kDa chain - Lysosomal protective protein 20 kDa chain |
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Gene names | Ctsa |
Organism | Mus musculus |
Protease Family | |
Protease ID | S10.002 |
Chromosome location | |
UniProt ID | P16675 |
12
N-termini
9
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPGTALSPLL LLLLLSWASR NEAAPDQDEI DCLPGLAKQP SFRQYSGYLR ASDSKHFHYW
70 80 90 100 110 120
FVESQNDPKN SPVVLWLNGG PGCSSLDGLL TEHGPFLIQP DGVTLEYNPY AWNLIANVLY
130 140 150 160 170 180
IESPAGVGFS YSDDKMYVTN DTEVAENNYE ALKDFFRLFP EYKDNKLFLT GESYAGIYIP
190 200 210 220 230 240
TLAVLVMQDP SMNLQGLAVG NGLASYEQND NSLVYFAYYH GLLGNRLWTS LQTHCCAQNK
250 260 270 280 290 300
CNFYDNKDPE CVNNLLEVSR IVGKSGLNIY NLYAPCAGGV PGRHRYEDTL VVQDFGNIFT
310 320 330 340 350 360
RLPLKRRFPE ALMRSGDKVR LDPPCTNTTA PSNYLNNPYV RKALHIPESL PRWDMCNFLV
370 380 390 400 410 420
NLQYRRLYQS MNSQYLKLLS SQKYQILLYN GDVDMACNFM GDEWFVDSLN QKMEVQRRPW
430 440 450 460 470
LVDYGESGEQ VAGFVKECSH ITFLTIKGAG HMVPTDKPRA AFTMFSRFLN KEPY
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
12 N-termini - 9 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P16675-8-unknown | PLLLLL... | 8 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P16675-24-unmodified | APDQDE... | 24 | N-TAILS | Overall CM. | Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... | 20208520 | |||
P16675-24-unmodified | APDQDE... | 24 | unknown | Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from... | 20208520 | ||||
P16675-24-unmodified | APDQDE... | 24 | N-TAILS | Overall CM. | Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9... | 20305284 | |||
P16675-24-unknown | APDQDE... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P16675-24-unknown | APDQDE... | 24 | N-TAILS | Overall CM. | auf dem Keller U.: A statistics-based platform for quantitative N-terminome... | 20305283 | |||
P16675-32-unknown | CLPGLA... | 32 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28451 | |||
P16675-32-unknown | CLPGLA... | 32 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28538 | |||
P16675-70-unknown | NSPVVL... | 70 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P16675-119-unknown | LYIESP... | 119 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P16675-140-unknown | NDTEVA... | 140 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P16675-159-unknown | FPEYKD... | 159 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P16675-321-unknown | LDPPCT... | 321 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P16675-334-unknown | YLNNPY... | 334 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33391 | |||
P16675-405-unknown | FVDSLN... | 405 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29750 | |||
P16675-405-unknown | FVDSLN... | 405 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28776 | |||
P16675-410-unknown | NQKMEV... | 410 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28777 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QDEIDC | 31 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28451 | |||
...QDEIDC | 31 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28538 | |||
...NSLVYF | 215 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000115514 | |||
...QNKCNF | 242 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000119814 | |||
...LLEVSR | 259 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000123413 | |||
...GDKVRL | 320 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TAPSNY | 333 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33391 | |||
...MGDEWF | 404 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29750 | |||
...MGDEWF | 404 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28776 | |||
...FVDSLN | 409 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28777 | |||
...NKEPY | 474 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP3_MOUSE | 31 | EIDC.|.CLPG | inferred from experiment | unknown | MEROPS | Vandenabeele P | Demon D et al.:Proteome-wide substrate analysi... (C14.003) | 19759058, |
CASP7_MOUSE | 31 | EIDC.|.CLPG | inferred from experiment | unknown | MEROPS | Vandenabeele P | Demon D et al.:Proteome-wide substrate analysi... (C14.003) | 19759058, |
MMP2_MOUSE | 333 | PSNY.|.YLNN | inferred from experiment | unknown | MEROPS | Overall CM | auf dem Keller U et al.:A statistics-based platform for... (M10.003) | 20305283, |
CATE_MOUSE | 404 | DEWF.|.FVDS | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> PPGB_MOUSE @404 | ||
CATD_MOUSE | 404 | DEWF.|.FVDS | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> PPGB_MOUSE @404 | ||
CATD_MOUSE | 409 | DSLN.|.NQKM | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> PPGB_MOUSE @409 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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