Q6PGL7: WASH complex subunit 2 {ECO:0000312|MGI:MGI:106463}

General Information

Protein names	- WASH complex subunit 2 {ECO:0000312\|MGI:MGI:106463}
Gene names	Fam21
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6PGL7

5 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of WASH complex subunit FAM21 - Isoform 2 of WASH complex subunit 2

Sequence View

        10         20         30         40         50         60
MNRTSPDSER PPASEPVWER PWSVEEIRRS SQNWSLAADA GLLQFLQEFS QQTISRTHEI
        70         80         90        100        110        120
KKQVDGLIQE TKATHCRLHN VFNDFLMLSN TQFIENRVYD EEVEEQVLKA EAEKAEQEKT
       130        140        150        160        170        180
REQKEIDLIP KVQEAVNYGL QVLDSAFEQL DIKAGNSDSE EDDANERVDL ILEPKDLYID
       190        200        210        220        230        240
RPLPYLIGSK LFMEQEDVGL GELSSEEGSV GSDRGSIVDS EDEKEEEESD EDFASHSDND
       250        260        270        280        290        300
QNQHTTQISD EEEDDDGDLF ADSEKEGDDI EDIEESAKSK RPTSFADELA ARIKGDISNQ
       310        320        330        340        350        360
RKEGQTDGKP QKTVKEKKER RTPADDEEDI LFPPPTLTDE DFSPFGSRGG LFSNGQGLFD
       370        380        390        400        410        420
DEDESDLFKE APRARPAQAP VSEELPPSPK PGKKIPAGAV SVLLGHPDVS GSTSAPSLKE
       430        440        450        460        470        480
LQKHGQPTPG KSSHLPTPAG LFDDDDNDND EDDNNFFMPS SSKPSKTDKV KSTAIIFDDD
       490        500        510        520        530        540
EGDLFKEKAE ALPAASVSQT HESKTRADKT IALPSSKNLK LVSETKTQKG LFSDEEDSED
       550        560        570        580        590        600
LFSSQSSSKP KSASLPSSQP PTSVSLFGDE DEEDSLFGSA AAKKQTSSLQ PQSQEKAKPS
       610        620        630        640        650        660
EQPSKKTSAL LFSSDEEDQW NIADSHTKLA SDNKSKGELW DSGATQGQEA KAVKKTNLFE
       670        680        690        700        710        720
DDDDDEVDLF AIAKDSQKKT QRTSLLFEDD AESGSSLFGL PPTSVPSATT KKESVPKVPL
       730        740        750        760        770        780
LFSDEEDSEV PSGVKPEDLK VDNARVSPEV GSADVASIAQ KEGLLPASDQ EAGGPSDIFS
       790        800        810        820        830        840
SSSPLDKGAK GRTRTVLSLF DEDEDKVEDE SSTCAPQDGR EKGLKTDSRP KSTGVFQDEE
       850        860        870        880        890        900
LLFSHKLQKD NDPDVDLFAG TKKIRSSVPS GGSLFGDDED DDLFSSAKTQ PVVPEKKGTL
       910        920        930        940        950        960
KKDHPVSLKN QDPLDSTQGS KEKSTWKTEP AQDSSGLTPF KSREPSSRIG KIQANLAINP
       970        980        990       1000       1010       1020
AALLPTVALQ IPGTKPVSSE LAFPSSEPGR SHILESVPTL PGSVEAGVSF DLPAQADTLH
      1030       1040       1050       1060       1070       1080
SANKSRVKVR GKRRPQTRAA RRLAAQESSE AEDVTVDRGP VAQLSSSPVL PNGHQPLLQP
      1090       1100       1110       1120       1130       1140
RMASGQTSSE TATAPPWEGG PVLSAADRSF FVKSRPQTGN EADLFDSGDI FPKSRGSQSV
      1150       1160       1170       1180       1190       1200
EGAGVMAGEP PSHSSGGRKE KSLAFPDLSE GSSTEDLFQS VKPRAAKNRN PFPLLEDEED
      1210       1220       1230       1240       1250       1260
LFADPRGKKN ERKPDSHQDS VSKTHDIFED DIFATEAIKP FPKKREKGRT LEPNLFDDNI
      1270       1280       1290       1300       1310       1320
DIFADLTVKP KEKSKKKVAA KSMFDDDTDD IFSSGLQAKA SKPKSQSAEA ASEQRSEHKV
      1330
ASIFDDPLNA FGSQ         10         20         30         40         50         60
MNRTSPDSER PPASEPVWER PWSVEEIRRS SQNWSLAADA GLLQFLQEFS QQTISRTHEI
        70         80         90        100        110        120
KKQVDGLIQE TKATHCRLHN VFNDFLMLSN TQFIENRVYD EEVEEQVLKA EAEKAEQEKT
       130        140        150        160        170        180
REQKEIDLIP KVQEAVNYGL QVLDSAFEQL DIKAGNSDSE EDDANERVDL ILEPKDLYID
       190        200        210        220        230        240
RPLPYLIGSK LFMEQEDVGL GELSSEEGSV GSDRGSIVDS EDEKEEEESD EDFASHSDND
       250        260        270        280        290        300
QNQHTTQISD EEEDDDGDLF ADSEKEGDDI EDIEESAKSK RPTSFADELA ARIKGDISNQ
       310        320        330        340        350        360
RKEGQTDGKP QKTVKEKKER RTPADDEEDI LFPPPTLTDE DFSPFGSRGG LFSNGQGLFD
       370        380        390        400        410        420
DEDESDLFKE APRARPAQAP VSEELPPSPK PGKKIPAGAV SVLLGHPDVS GSTSAPSLKE
       430        440        450        460        470        480
LQKHGQPTPG KSSHLPTPAG LFDDDDNDND EDDNNFFMPS SSKPSKTDKV KSTAIIFDDD
       490        500        510        520        530        540
EGDLFKEKAE ALPAASVSQT HESKTRADKT IALPSSKNLK LVSETKTQKG LFSDEEDSED
       550        560        570        580        590        600
LFSSQSSSKP KSASLPSSQP PTSVSLFGDE DEEDSLFGSA AAKKQTSSLQ PQSQEKAKPS
       610        620        630        640        650        660
EQPSKKTSAL LFSSDEEDQW NIADSHTKLA SDNKSKGELW DSGATQGQEA KAVKKTNLFE
       670        680        690        700        710        720
DDDDDEVDLF AIAKDSQKKT QRTSLLFEDD AESGSSLFGL PPTSVPSATT KKESVPKVPL
       730        740        750        760        770        780
LFSDEEDSEV PSGVKPEDLK VDNARVSPEV GSADVASIAQ KEGLLPASDQ EAGGPSDIFS
       790        800        810        820        830        840
SSSPLDKGAK GRTRTVLSLF DEDEDKVEDE SSTCAPQDGR EKGLKTDSRP KSTGVFQDEE
       850        860        870        880        890        900
LLFSHKLQKD NDPDVDLFAG TKKIRSSVPS GGSLFGDDED DDLFSSAKTQ PVVPEKKGTL
       910        920        930        940        950        960
KKDHPVSLKN QDPLDSTQGS KEKSTWKTEP AQDSSGLTPF KSREPSSRIG KIQANLAINP
       970        980        990       1000       1010       1020
AALLPTVALQ IPGTKPVSSE LAFPSSEPGR SHILESVPTL PGSVEAGVSF DLPAQADTLH
      1030       1040       1050       1060       1070       1080
SANKSRVKVR GKRRPQTRAA RRLAAQESSE AEDVTVDRGP VAQLSSSPVL PNGHQPLLQP
      1090       1100       1110       1120       1130       1140
RMASGQTSSE TATAPPWEGG PVLSAADRSF FVKSRPQTGN EADLFDSGDI FPKSRGSQSV
      1150       1160       1170       1180       1190       1200
EGAGVMAGEP PSHSSGGRKE KSLAFPDLSE GSSTEDLFQS VKPRAAKNRN PFPLLEDEED
      1210       1220       1230       1240       1250       1260
LFADPRGKKN ERKPDSHQDS VSKTHDIFED DIFATEAIKP FPKKREKGRT LEPNLFDDNI
      1270       1280       1290       1300       1310       1320
DIFADLTVKP KEKSKKKVAA KSMFDDDTDD IFSSGLQAKA SKPKSQSAEA ASEQRSEHKV
      1330
ASIFDDPLNA FGSQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6PGL7-1-unknown	MNRTSP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6PGL7-1-unknown	MNRTSP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74760
Q6PGL7-669-unknown	LFAIAK...	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28499
Q6PGL7-669-unknown	LFAIAK...	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28578
Q6PGL7-669-unknown	LFAIAK...	669	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155531
Q6PGL7-670-unknown	FAIAKD...	670	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29206
Q6PGL7-670-unknown	FAIAKD...	670	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30628
Q6PGL7-670-unknown	FAIAKD...	670	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155542
Q6PGL7-858-unknown	FAGTKK...	858	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29208
Q6PGL7-858-unknown	FAGTKK...	858	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30630
Q6PGL7-1234-unknown	ATEAIK...	1234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29209
Q6PGL7-1234-unknown	ATEAIK...	1234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157499

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDEVDL	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28499
...DDEVDL	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28578
...DDEVDL	668	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138969
...DEVDLF	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29206
...DEVDLF	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30628
...DEVDLF	669	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138980
...PDVDLF	857	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29208
...PDVDLF	857	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30630
...EDDIFA	1233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29209
...EDDIFA	1233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140997
...AFGSQ	1334	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AFGSQ	1334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70378

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	668	EVDL.\|.LFAI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	668	EVDL.\|.LFAI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CATD_MOUSE	669	VDLF.\|.FAIA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> FAM21_MOUSE @669
CATE_MOUSE	669	VDLF.\|.FAIA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> FAM21_MOUSE @669
CATD_MOUSE	857	VDLF.\|.FAGT	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> FAM21_MOUSE @857
CATE_MOUSE	857	VDLF.\|.FAGT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> FAM21_MOUSE @857
CATD_MOUSE	1233	DIFA.\|.ATEA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> FAM21_MOUSE @1233

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)