Q9JLM8: Serine/threonine-protein kinase DCLK1
Protein names | - Serine/threonine-protein kinase DCLK1 - 2.7.11.1 - Doublecortin-like and CAM kinase-like 1 - Doublecortin-like kinase 1 |
---|---|
Gene names | Dclk1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9JLM8 |
2
N-termini
2
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR
70 80 90 100 110 120
FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL
130 140 150 160 170 180
DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GGPSEVRENK
190 200 210 220 230 240
DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK
250 260 270 280 290 300
QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASA SRRGTTKSPG
310 320 330 340 350 360
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRISQHG GSSTSLSSTK
370 380 390 400 410 420
VCSSMDENDG PGEGDELGRR HSLQRGWRRE ESEEGFQIPA TITERYKVGR TIGDGNFAVV
430 440 450 460 470 480
KECIERSTAR EYALKIIKKS KCRGKEHMIQ NEVSILRRVK HPNIVLLIEE MDVPTELYLV
490 500 510 520 530 540
MELVKGGDLF DAITSTSKYT ERDASGMLYN LASAIKYLHS LNIVHRDIKP ENLLVYEHQD
550 560 570 580 590 600
GSKSLKLGDF GLATIVDGPL YTVCGTPTYV APEIIAETGY GLKVDIWAAG VITYILLCGF
610 620 630 640 650 660
PPFRGSGDDQ EVLFDQILMG QVDFPSPYWD NVSDSAKELI NMMLLVNVDQ RFSAVQVLEH
670 680 690 700 710 720
PWVNDDGLPE NEHQLSVAGK IKKHFNTGPK PSSTAAGVSV IATTALDKER QVFRRRRNQD
730 740 750
VRSRYKAQPA PPELNSESED YSPSSSETVR SPNSPF
Isoforms
- Isoform 2 of Serine/threonine-protein kinase DCLK1Sequence View
10 20 30 40 50 60
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR
70 80 90 100 110 120
FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL
130 140 150 160 170 180
DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GGPSEVRENK
190 200 210 220 230 240
DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK
250 260 270 280 290 300
QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASA SRRGTTKSPG
310 320 330 340 350 360
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRISQHG GSSTSLSSTK
370 380 390 400 410 420
VCSSMDENDG PGEGDELGRR HSLQRGWRRE ESEEGFQIPA TITERYKVGR TIGDGNFAVV
430 440 450 460 470 480
KECIERSTAR EYALKIIKKS KCRGKEHMIQ NEVSILRRVK HPNIVLLIEE MDVPTELYLV
490 500 510 520 530 540
MELVKGGDLF DAITSTSKYT ERDASGMLYN LASAIKYLHS LNIVHRDIKP ENLLVYEHQD
550 560 570 580 590 600
GSKSLKLGDF GLATIVDGPL YTVCGTPTYV APEIIAETGY GLKVDIWAAG VITYILLCGF
610 620 630 640 650 660
PPFRGSGDDQ EVLFDQILMG QVDFPSPYWD NVSDSAKELI NMMLLVNVDQ RFSAVQVLEH
670 680 690 700 710 720
PWVNDDGLPE NEHQLSVAGK IKKHFNTGPK PSSTAAGVSV IATTALDKER QVFRRRRNQD
730 740 750
VRSRYKAQPA PPELNSESED YSPSSSETVR SPNSPF
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9JLM8-1-unknown | MSFGRD... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9JLM8-1-unknown | MSFGRD... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72447 | |||
Q9JLM8-370-unknown | GPGEGD... | 370 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28525 | |||
Q9JLM8-370-unknown | GPGEGD... | 370 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28618 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...MDENDG | 369 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28525 | |||
...MDENDG | 369 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28618 | |||
...PNSPF | 756 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP3_MOUSE | 369 | ENDG.|.GPGE | inferred from experiment | unknown | MEROPS | Vreugdenhil E | Kruidering M et al.:Caspase-mediated cleavage of th... (C14.003) | 11479289, |
CASP8_MOUSE | 369 | ENDG.|.GPGE | inferred from experiment | unknown | MEROPS | Vreugdenhil E | Kruidering M et al.:Caspase-mediated cleavage of th... (C14.003) | 11479289, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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