P62737: Actin, aortic smooth muscle

General Information

Protein names	- Actin, aortic smooth muscle - Alpha-actin-2 - Actin, aortic smooth muscle, intermediate form
Gene names	Acta2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P62737

18 N-termini

18 C-termini

24 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA
        70         80         90        100        110        120
QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK
       130        140        150        160        170        180
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL
       190        200        210        220        230        240
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK
       250        260        270        280        290        300
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
       310        320        330        340        350        360
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS
       370
KQEYDEAGPS IVHRKCF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

18 N-termini - 18 C-termini - 24 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P62737-3-Acetylation	EEEDST...	3	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P62737-19-unknown	CKAGFA...	19		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33693
P62737-31-unknown	AVFPSI...	31		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33694
P62737-45-unknown	VMVGMG...	45		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33695
P62737-47-unknown	VGMGQK...	47		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30184
P62737-56-unknown	VGDEAQ...	56		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30185
P62737-107-unknown	LTEAPL...	107		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28988
P62737-107-unknown	LTEAPL...	107		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33696
P62737-107-unknown	LTEAPL...	107		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30186
P62737-139-unknown	QAVLSL...	139		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30187
P62737-142-unknown	LSLYAS...	142		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30188
P62737-192-unknown	MKILTE...	192		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30189
P62737-230-unknown	ATAASS...	230		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28989
P62737-234-unknown	SSSSLE...	234		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33697
P62737-235-unknown	SSSLEK...	235		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33698
P62737-238-unknown	LEKSYE...	238		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33699
P62737-247-unknown	GQVITI...	247		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28481
P62737-247-unknown	GQVITI...	247		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32368
P62737-247-unknown	GQVITI...	247		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28560
P62737-247-unknown	GQVITI...	247		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28362
P62737-248-unknown	QVITIG...	248		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33700
P62737-300-unknown	VLSGGT...	300		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33701
P62737-300-unknown	VLSGGT...	300		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30190
P62737-302-unknown	SGGTTM...	302		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28990
P62737-302-unknown	SGGTTM...	302		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30191

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NGSGLC	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33693
...DDAPRA	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33694
...PRHQGV	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33695
...HQGVMV	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30184
...QKDSYV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30185
...EHPTLL	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28988
...EHPTLL	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33696
...EHPTLL	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30186
...MYVAIQ	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30187
...AIQAVL	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30188
...LTDYLM	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30189
...FENEMA	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28989
...MATAAS	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33697
...ATAASS	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33698
...ASSSSL	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33699
...YELPDG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28481
...YELPDG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32368
...YELPDG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28560
...YELPDG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28362
...ELPDGQ	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33700
...LYANNV	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33701
...LYANNV	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30190
...ANNVLS	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28990
...ANNVLS	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30191
...HRKCF	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	18	SGLC.\|.CKAG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	30	APRA.\|.AVFP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	44	HQGV.\|.VMVG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	46	GVMV.\|.VGMG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @46
CATE_MOUSE	55	DSYV.\|.VGDE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @55
CATD_MOUSE	106	PTLL.\|.LTEA	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
MMP2_MOUSE	106	PTLL.\|.LTEA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	106	PTLL.\|.LTEA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @106
CATE_MOUSE	138	VAIQ.\|.QAVL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @138
CATE_MOUSE	141	QAVL.\|.LSLY	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @141
CATE_MOUSE	191	DYLM.\|.MKIL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @191
CATD_MOUSE	229	NEMA.\|.ATAA	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
MMP2_MOUSE	233	TAAS.\|.SSSS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	234	AASS.\|.SSSL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	237	SSSL.\|.LEKS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CASP3_MOUSE	246	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_MOUSE	246	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_MOUSE	246	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	246	LPDG.\|.GQVI	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
MMP2_MOUSE	247	PDGQ.\|.QVIT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	299	ANNV.\|.VLSG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	299	ANNV.\|.VLSG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @299
CATD_MOUSE	301	NVLS.\|.SGGT	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	301	NVLS.\|.SGGT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTA_MOUSE @301

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)