P53349: Mitogen-activated protein kinase kinase kinase 1
| Protein names | - Mitogen-activated protein kinase kinase kinase 1 - 2.7.11.25 - MAPK/ERK kinase kinase 1 - MEK kinase 1 - MEKK 1 |
|---|---|
| Gene names | Map3k1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P53349 |
3
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGG GGALQGSGAP AAGAAGLLRE PGSAGRERAD
70 80 90 100 110 120
WRRRQLRKVR SVELDQLPEQ PLFLAAASPP CPSTSPSPEP ADAAAGASRF QPAAGPPPPG
130 140 150 160 170 180
AASRCGSHSA ELAAARDSGA RSPAGAEPPS AAAPSGREME NKETLKGLHK MEDRPEERMI
190 200 210 220 230 240
REKLKATCMP AWKHEWLERR NRRGPVVVKP IPIKGDGSEV NNLAAEPQGE GQAGSAAPAP
250 260 270 280 290 300
KGRRSPSPGS SPSGRSVKPE SPGVRRKRVS PVPFQSGRIT PPRRAPSPDG FSPYSPEETS
310 320 330 340 350 360
RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ NCSCGRGAFC IHLLFVMLRV
370 380 390 400 410 420
FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR NTIQKFVSRM SNSHTLSSSS
430 440 450 460 470 480
TSTSSSENSI KDEEEQMCPI CLLGMLDEES LTVCEDGCRN KLHHHCMSIW AEECRRNREP
490 500 510 520 530 540
LICPLCRSKW RSHDFYSHEL SSPVESPASL RAVQQPSSPQ QPVAGSQRRN QESSFNLTHF
550 560 570 580 590 600
GTQQIPSAYK DLAEPWIQVF GMELVGCLFS RNWNVREMAL RRLSHDVSGA LLLANGESTG
610 620 630 640 650 660
NSGGGSGGSL SAGAASGSSQ PSISGDVVEA CCSVLSIVCA DPVYKVYVAA LKTLRAMLVY
670 680 690 700 710 720
TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS TVLELCKGQA GELAVGREIL
730 740 750 760 770 780
KAGSIGVGGV DYVLSCILGN QAESNNWQEL LGRLCLIDRL LLEFPAEFYP HIVSTDVSQA
790 800 810 820 830 840
EPVEIRYKKL LSLLTFALQS IDNSHSMVGK LSRRIYLSSA RMVTAVPAVF SKLVTMLNAS
850 860 870 880 890 900
GSTHFTRMRR RLMAIADEVE IAEVIQLGVE DTVDGHQDSL QAVAPTSCLE NSSLEHTVHR
910 920 930 940 950 960
EKTGKGLSAT RLSASSEDIS DRLAGVSVGL PSSTTTEQPK PAVQTKGRPH SQCLNSSPLS
970 980 990 1000 1010 1020
HAQLMFPAPS APCSSAPSVP DISKHRPQAF VPCKIPSASP QTQRKFSLQF QRNCSEHRDS
1030 1040 1050 1060 1070 1080
DQLSPVFTQS RPPPSSNIHR PKPSRPVPGS TSKLGDATKS SMTLDLGSAS RCDDSFGGGG
1090 1100 1110 1120 1130 1140
NSGNAVIPSD ETVFTPVEDK CRLDVNTELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE
1150 1160 1170 1180 1190 1200
KAENDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
1210 1220 1230 1240 1250 1260
QQDTPETLPG HTKAKQPYRE DAEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN
1270 1280 1290 1300 1310 1320
TSSEQEEVVE ALREEIRMMG HLNHPNIIRM LGATCEKSNY NLFIEWMAGG SVAHLLSKYG
1330 1340 1350 1360 1370 1380
AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG
1390 1400 1410 1420 1430 1440
TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA
1450 1460 1470 1480 1490
LIFKIASATT APSIPSHLSP GLRDVAVRCL ELQPQDRPPS RELLKHPVFR TTW
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P53349-2-unknown | MAAAAG... | 1 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| P53349-2-unknown | MAAAAG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P53349-2-Acetylation | AAAAGD... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
| P53349-2-Acetylation | AAAAGD... | 2 | acetylation- | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | ||
| P53349-875-unknown | GHQDSL... | 875 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28474 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...EDTVDG | 874 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28474 | |||
| ...FRTTW | 1493 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CASP3_MOUSE | 874 | TVDG.|.GHQD | inferred from experiment | unknown | MEROPS | Johnson GL | Widmann C et al.:Caspase-dependent cleavage of s... (C14.003) | 9507028, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|