TopFIND 4.0

P23804: E3 ubiquitin-protein ligase Mdm2

General Information

Protein names
- E3 ubiquitin-protein ligase Mdm2
- 2.3.2.27 {ECO:0000269|PubMed:14642282}
- Double minute 2 protein
- Oncoprotein Mdm2
- RING-type E3 ubiquitin transferase Mdm2 {ECO:0000305}
- p53-binding protein Mdm2
Gene names Mdm2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID P23804

3

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM KEIIFYIGQY 
        70         80         90        100        110        120 
IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVAV SQQDSGTSLS 
       130        140        150        160        170        180 
ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI SRLSTSSRRR SISETEENTD ELPGERHRKR 
       190        200        210        220        230        240 
RRSLSFDPSL GLCELREMCS GGSSSSSSSS SESTETPSHQ DLDDGVSEHS GDCLDQDSVS 
       250        260        270        280        290        300 
DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ TGESDTDSFE GDPEISLADY 
       310        320        330        340        350        360 
WKCTSCNEMN PPLPSHCKRC WTLRENWLPD DKGKDKVEIS EKAKLENSAQ AEEGLDVPDG 
       370        380        390        400        410        420 
KKLTENDAKE PCAEEDSEEK AEQTPLSQES DDYSQPSTSS SIVYSSQESV KELKEETQDK 
       430        440        450        460        470        480 
DESVESSFSL NAIEPCVICQ GRPKNGCIVH GKTGHLMSCF TCAKKLKKRN KPCPVCRQPI 
   
QMIVLTYFN

Isoforms

- Isoform Mdm2-p76 of E3 ubiquitin-protein ligase Mdm2

Sequence View

        10         20         30         40         50         60 
MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM KEIIFYIGQY 
        70         80         90        100        110        120 
IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVAV SQQDSGTSLS 
       130        140        150        160        170        180 
ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI SRLSTSSRRR SISETEENTD ELPGERHRKR 
       190        200        210        220        230        240 
RRSLSFDPSL GLCELREMCS GGSSSSSSSS SESTETPSHQ DLDDGVSEHS GDCLDQDSVS 
       250        260        270        280        290        300 
DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ TGESDTDSFE GDPEISLADY 
       310        320        330        340        350        360 
WKCTSCNEMN PPLPSHCKRC WTLRENWLPD DKGKDKVEIS EKAKLENSAQ AEEGLDVPDG 
       370        380        390        400        410        420 
KKLTENDAKE PCAEEDSEEK AEQTPLSQES DDYSQPSTSS SIVYSSQESV KELKEETQDK 
       430        440        450        460        470        480 
DESVESSFSL NAIEPCVICQ GRPKNGCIVH GKTGHLMSCF TCAKKLKKRN KPCPVCRQPI 
   
QMIVLTYFN



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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)