P63038: 60 kDa heat shock protein, mitochondrial

General Information

Protein names	- 60 kDa heat shock protein, mitochondrial - 5.6.1.7 {ECO:0000250\|UniProtKB:P10809} - 60 kDa chaperonin - Chaperonin 60 - CPN60 - HSP-65 - Heat shock protein 60 - HSP-60 - Hsp60 - Mitochondrial matrix protein P1
Gene names	Hspd1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P63038

17 N-termini

15 C-termini

20 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLRLPTVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR
        70         80         90        100        110        120
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA
       130        140        150        160        170        180
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK
       190        200        210        220        230        240
DIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ
       250        260        270        280        290        300
DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV
       310        320        330        340        350        360
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQAH DLGKVGEVIV TKDDAMLLKG
       370        380        390        400        410        420
KGDKAHIEKR IQEITEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR
       430        440        450        460        470        480
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLKPANED QKIGIEIIKR ALKIPAMTIA
       490        500        510        520        530        540
KNAGVEGSLI VEKILQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT
       550        560        570
TAEAVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

Isoforms

- Isoform 2 of 60 kDa heat shock protein, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 15 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63038-27-unknown	AKDVKF...	27	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63038-47-unknown	LADAVA...	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30229
P63038-48-unknown	ADAVAV...	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29018
P63038-50-unknown	AVAVTM...	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33732
P63038-50-unknown	AVAVTM...	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28363
P63038-101-unknown	VANNTN...	101	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28364
P63038-204-unknown	GKTLND...	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28482
P63038-204-unknown	GKTLND...	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28561
P63038-254-unknown	VQSIVP...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33733
P63038-280-unknown	GEALST...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28483
P63038-280-unknown	GEALST...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28562
P63038-300-unknown	VKAPGF...	300	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33734
P63038-316-unknown	MAIATG...	316	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70495
P63038-405-unknown	KVGGTS...	405	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30230
P63038-405-unknown	KVGGTS...	405	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29019
P63038-405-unknown	KVGGTS...	405	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141802
P63038-406-unknown	VGGTSD...	406		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63038-406-unknown	VGGTSD...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160509
P63038-412-unknown	VEVNEK...	412	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30232
P63038-412-unknown	VEVNEK...	412	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142232
P63038-436-unknown	IVLGGG...	436	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30234
P63038-436-unknown	IVLGGG...	436	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143505
P63038-514-unknown	VEKGII...	514	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30236
P63038-514-unknown	VEKGII...	514	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29021
P63038-514-unknown	VEKGII...	514	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146541
P63038-532-unknown	AAGVAS...	532	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28484
P63038-532-unknown	AAGVAS...	532	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28563
P63038-532-unknown	AAGVAS...	532	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147230
P63038-538-unknown	LLTTAE...	538	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33735
P63038-538-unknown	LLTTAE...	538	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147491

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QGVDLL	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30229
...GVDLLA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29018
...DLLADA	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33732
...DLLADA	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28363
...KLVQDV	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28364
...ITVKDG	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28482
...ITVKDG	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28561
...KKISSV	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33733
...AEDVDG	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28483
...AEDVDG	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28562
...LQVVAV	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33734
...GVAVLK	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30230
...GVAVLK	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29019
...GVAVLK	404	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124983
...GGTSDV	411	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30232
...GGTSDV	411	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125420
...AVEEGI	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30234
...AVEEGI	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126745
...DFVNMV	513	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30236
...DFVNMV	513	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29021
...DFVNMV	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129849
...TALLDA	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28484
...TALLDA	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28563
...TALLDA	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130573
...AGVASL	537	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33735
...AGVASL	537	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130841
...GGGMF	573	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GGGMF	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66113

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	46	VDLL.\|.LADA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> CH60_MOUSE @46
CATD_MOUSE	47	DLLA.\|.ADAV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> CH60_MOUSE @47
MMP2_MOUSE	49	LADA.\|.AVAV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CASP1_MOUSE	49	LADA.\|.AVAV	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP1_MOUSE	100	VQDV.\|.VANN	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP3_MOUSE	203	VKDG.\|.GKTL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	203	VKDG.\|.GKTL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	253	ISSV.\|.VQSI	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CASP3_MOUSE	279	DVDG.\|.GEAL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	279	DVDG.\|.GEAL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	299	VVAV.\|.VKAP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	404	AVLK.\|.KVGG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> CH60_MOUSE @404
CATD_MOUSE	404	AVLK.\|.KVGG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> CH60_MOUSE @404
CATE_MOUSE	411	TSDV.\|.VEVN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> CH60_MOUSE @411
CATE_MOUSE	435	EEGI.\|.IVLG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> CH60_MOUSE @435
CATE_MOUSE	513	VNMV.\|.VEKG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> CH60_MOUSE @513
CATD_MOUSE	513	VNMV.\|.VEKG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> CH60_MOUSE @513
CASP3_MOUSE	531	LLDA.\|.AAGV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	531	LLDA.\|.AAGV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	537	VASL.\|.LLTT	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CH60_MOUSE @537

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)