Q91VR5: ATP-dependent RNA helicase DDX1

General Information

Protein names	- ATP-dependent RNA helicase DDX1 - 3.6.4.13 - DEAD box protein 1
Gene names	Ddx1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91VR5

5 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS GKTGAFSIPV
        70         80         90        100        110        120
IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS AFAIGSDGLC CQSREVKEWH
       130        140        150        160        170        180
GCRGTRGLLK GKHYYEVSCH DQGLCRVGWS TMQASLDLGT DKFGFGFGGT GKKSHNKQFD
       190        200        210        220        230        240
NYGEEFTMHD TIGCYLDIDK GHVKFSKNGK DLGLAFEIPA HIKNQALFPA CVLKNAELKF
       250        260        270        280        290        300
NFGEEEFKFP PKDGFVALSK APDNYIVKSQ HTGNAQVSQT KFLPNAPKAL IVEPSRELAE
       310        320        330        340        350        360
QTLNNVKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLDNGV DIVVGTPGRL DDLVSTGKLN
       370        380        390        400        410        420
LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQITCDGKR LQVIVCSATL HSFDVKKLSE
       430        440        450        460        470        480
KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDKLWERLG KNHIRTDDVH AKDNTRPGAN
       490        500        510        520        530        540
SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFMQQG GGPDKKGHQF
       550        560        570        580        590        600
SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV
       610        620        630        640        650        660
HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSNRGKGCYN TRLKEDGGCT IWYNEMQLLS
       670        680        690        700        710        720
EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGN YKGHVDVLAP TVQELAALEK
       730        740
EAQTSFLHLG YLPNQLFRTF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q91VR5-1-unknown	MAAFSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q91VR5-11-unknown	PEIAQA...	11	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q91VR5-374-unknown	GLLSQG...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28517
Q91VR5-374-unknown	GLLSQG...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28596
Q91VR5-501-unknown	IKEHKM...	501	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34136
Q91VR5-686-unknown	GKVTYG...	686	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28518
Q91VR5-686-unknown	GKVTYG...	686	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28597

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDEADG	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28517
...LDEADG	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28596
...YAVRAI	500	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34136
...VDEFDG	685	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28518
...VDEFDG	685	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28597
...LFRTF	740	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_MOUSE	373	EADG.\|.GLLS	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	373	EADG.\|.GLLS	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
MMP2_MOUSE	500	VRAI.\|.IKEH	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CASP3_MOUSE	685	EFDG.\|.GKVT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	685	EFDG.\|.GKVT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)