Q9WUK2: Eukaryotic translation initiation factor 4H

General Information

Protein names	- Eukaryotic translation initiation factor 4H - eIF-4H - Williams-Beuren syndrome chromosomal region 1 protein homolog
Gene names	Eif4h
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9WUK2

8 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA
        70         80         90        100        110        120
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK
       130        140        150        160        170        180
QDKGGFGFRK GGPDDRGMGG SRESRGGWDS RDDFNSGYRD DFLGGRGGSR PGDRRAGPPM
       190        200        210        220        230        240
GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE

EVVQKEQE

Isoforms

- Isoform Short of Eukaryotic translation initiation factor 4H

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9WUK2-1-unknown	MADFDT...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77568
Q9WUK2-2-unknown	MADFDT...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9WUK2-2-unknown	MADFDT...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9WUK2-2-Acetylation	ADFDTY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9WUK2-2-Acetylation	ADFDTY...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111587
Q9WUK2-2-Acetylation	ADFDTY...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9WUK2-5-unknown	DTYDDR...	5		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9WUK2-5-unknown	DTYDDR...	5		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194640
Q9WUK2-58-unknown	IDAIFK...	58		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32593
Q9WUK2-58-unknown	IDAIFK...	58		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139729
Q9WUK2-90-unknown	DEVDSL...	90		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29441
Q9WUK2-90-unknown	DEVDSL...	90		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31343
Q9WUK2-90-unknown	DEVDSL...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141793
Q9WUK2-94-unknown	SLKEAL...	94		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28421
Q9WUK2-94-unknown	SLKEAL...	94		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28526
Q9WUK2-94-unknown	SLKEAL...	94		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28605
Q9WUK2-94-unknown	SLKEAL...	94		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142054
Q9WUK2-96-unknown	KEALTY...	96		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28423
Q9WUK2-96-unknown	KEALTY...	96		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142156

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TVQGDI	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32593
...TVQGDI	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122828
...CYVEFD	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29441
...CYVEFD	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31343
...CYVEFD	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124974
...FDEVDS	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28421
...FDEVDS	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28526
...FDEVDS	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28605
...FDEVDS	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125237
...EVDSLK	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28423
...EVDSLK	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125342
...QKEQE	248	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKEQE	248	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73186

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	57	QGDI.\|.IDAI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATD_MOUSE	89	VEFD.\|.DEVD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF4H_MOUSE @89
CATE_MOUSE	89	VEFD.\|.DEVD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF4H_MOUSE @89
CASP1_MOUSE	93	EVDS.\|.SLKE	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP3_MOUSE	93	EVDS.\|.SLKE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP7_MOUSE	93	EVDS.\|.SLKE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
CASP1_MOUSE	95	DSLK.\|.KEAL	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)