P13020: Gelsolin

General Information

Protein names	- Gelsolin - Actin-depolymerizing factor - ADF - Brevin
Gene names	Gsn
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P13020

28 N-termini

9 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPYRSSLLC ALLLLALCAL SPSHAATTSR GRAQERAPQS RVSEARPSTM VVEHPEFLKA
        70         80         90        100        110        120
GKEPGLQIWR VEKFDLVPVP PNLYGDFFTG DAYVILKTVQ LRNGNLQYDL HYWLGNECSQ
       130        140        150        160        170        180
DESGAAAIFT VQLDDYLNGR AVQHREVQGF ESSTFSGYFK SGLKYKKGGV ASGFKHVVPN
       190        200        210        220        230        240
EVVVQRLFQV KGRRVVRATE VPVSWDSFNN GDCFILDLGN NIYQWCGSGS NKFERLKATQ
       250        260        270        280        290        300
VSKGIRDNER SGRAQVHVSE EGGEPEAMLQ VLGPKPALPE GTEDTAKEDA ANRRLAKLYK
       310        320        330        340        350        360
VSNGAGSMSV SLVADENPFA QGALRSEDCF ILDHGRDGKI FVWKGKQANM EERKAALKTA
       370        380        390        400        410        420
SDFISKMQYP RQTQVSVLPE GGETPLFKQF FKNWRDPDQT DGPGLGYLSS HIANVERVPF
       430        440        450        460        470        480
DAATLHTSTA MAAQHGMDDD GTGQKQIWRI EGSNKVPVDP ATYGQFYGGD SYIILYNYRH
       490        500        510        520        530        540
GGRQGQIIYN WQGAQSTQDE VAASAILTAQ LDEELGGTPV QSRVVQGKEP AHLMSLFGGK
       550        560        570        580        590        600
PMIIYKGGTS RDGGQTAPAS IRLFQVRASS SGATRAVEVM PKSGALNSND AFVLKTPSAA
       610        620        630        640        650        660
YLWVGAGASE AEKTGAQELL KVLRSQHVQV EEGSEPDAFW EALGGKTAYR TSPRLKDKKM
       670        680        690        700        710        720
DAHPPRLFAC SNRIGRFVIE EVPGELMQED LATDDVMLLD TWDQVFVWVG KDSQEEEKTE
       730        740        750        760        770        780
ALTSAKRYIE TDPANRDRRT PITVVRQGFE PPSFVGWFLG WDDNYWSVDP LDRALAELAA

Isoforms

- Isoform 2 of Gelsolin

Sequence View

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Protein Neighborhood

Domains & Features

28 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13020-26-unknown	ATTSRG...	26	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13020-50-unknown	MVVEHP...	50	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75878
P13020-51-unmodified	VVEHPE...	51		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-51-unknown	VVEHPE...	51		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P13020-51-unknown	VVEHPE...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160636
P13020-224-unknown	QWCGSG...	224	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P13020-224-unknown	QWCGSG...	224	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198282
P13020-311-unmodified	SLVADE...	311		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-311-unknown	SLVADE...	311	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161067
P13020-313-unknown	VADENP...	313	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29708
P13020-313-unknown	VADENP...	313	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28755
P13020-313-unknown	VADENP...	313	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148942
P13020-324-unknown	LRSEDC...	324	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33358
P13020-324-unknown	LRSEDC...	324	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149234
P13020-326-unknown	SEDCFI...	326	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161070
P13020-326-unmodified	SEDCFI...	326		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-402-unmodified	GPGLGY...	402		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-402-unknown	GPGLGY...	402	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28448
P13020-402-unknown	GPGLGY...	402	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151002
P13020-404-unmodified	GLGYLS...	404		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-404-unknown	GLGYLS...	404	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161060
P13020-406-unmodified	GYLSSH...	406		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-406-unknown	GYLSSH...	406	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161063
P13020-408-unknown	LSSHIA...	408	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161065
P13020-408-unknown	LSSHIA...	408	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13020-408-unknown	LSSHIA...	408	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P13020-408-unmodified	LSSHIA...	408		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-409-unknown	SSHIAN...	409	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161072
P13020-409-unmodified	SSHIAN...	409		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-434-unknown	QHGMDD...	434	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33360
P13020-434-unknown	QHGMDD...	434	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151734
P13020-508-unknown	TAQLDE...	508	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28757
P13020-508-unknown	TAQLDE...	508	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152897
P13020-509-unknown	AQLDEE...	509	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28759
P13020-509-unknown	AQLDEE...	509	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152912
P13020-512-unknown	DEELGG...	512	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29710
P13020-512-unknown	DEELGG...	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152940
P13020-537-unknown	FGGKPM...	537	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28761
P13020-537-unknown	FGGKPM...	537	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153282
P13020-614-unmodified	TGAQEL...	614		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P13020-614-unknown	TGAQEL...	614	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161074

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MSVSLV	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29708
...MSVSLV	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28755
...MSVSLV	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132323
...FAQGAL	323	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33358
...FAQGAL	323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132619
...PDQTDG	401	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28448
...PDQTDG	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134405
...TAMAAQ	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33360
...TAMAAQ	433	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135139
...ASAILT	507	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28757
...ASAILT	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136322
...SAILTA	508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28759
...SAILTA	508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136338
...LTAQLD	511	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29710
...LTAQLD	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136366
...HLMSLF	536	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28761
...HLMSLF	536	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136706
...AELAA	780	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AELAA	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71496

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	312	VSLV.\|.VADE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> GELS_MOUSE @312
CATD_MOUSE	312	VSLV.\|.VADE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> GELS_MOUSE @312
MMP2_MOUSE	323	QGAL.\|.LRSE	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> GELS_MOUSE @323
CASP3_MOUSE	401	QTDG.\|.GPGL	inferred from experiment	unknown	MEROPS	Williams LT	Kothakota S et al.:Caspase-3-generated fragment of... (C14.004)	9323209,
MMP2_MOUSE	433	MAAQ.\|.QHGM	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> GELS_MOUSE @433
CATD_MOUSE	507	AILT.\|.TAQL	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> GELS_MOUSE @507
CATD_MOUSE	508	ILTA.\|.AQLD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> GELS_MOUSE @508
CATE_MOUSE	511	AQLD.\|.DEEL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> GELS_MOUSE @511
CATD_MOUSE	536	MSLF.\|.FGGK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> GELS_MOUSE @536

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)