TopFIND 4.0

P70343: Caspase-4

General Information

Protein names
- Caspase-4
- CASP-4
- 3.4.22.64 {ECO:0000250|UniProtKB:P49662}
- Caspase-11
- CASP-11
- Protease ICH-3 {ECO:0000303|PubMed:8702803}
- Caspase-4 subunit p10
- Caspase-4 subunit p20

Gene names Casp4
Organism Mus musculus
Protease Family C14.012
Protease ID C14.012
Chromosome location
UniProt ID P70343

2

N-termini

3

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MAENKHPDKP LKVLEQLGKE VLTEYLEKLV QSNVLKLKEE DKQKFNNAER SDKRWVFVDA 
        70         80         90        100        110        120 
MKKKHSKVGE MLLQTFFSVD PGSHHGEANL EMEEPEESLN TLKLCSPEEF TRLCREKTQE 
       130        140        150        160        170        180 
IYPIKEANGR TRKALIICNT EFKHLSLRYG ANFDIIGMKG LLEDLGYDVV VKEELTAEGM 
       190        200        210        220        230        240 
ESEMKDFAAL SEHQTSDSTF LVLMSHGTLH GICGTMHSEK TPDVLQYDTI YQIFNNCHCP 
       250        260        270        280        290        300 
GLRDKPKVII VQACRGGNSG EMWIRESSKP QLCRGVDLPR NMEADAVKLS HVEKDFIAFY 
       310        320        330        340        350        360 
STTPHHLSYR DKTGGSYFIT RLISCFRKHA CSCHLFDIFL KVQQSFEKAS IHSQMPTIDR 
       370    
ATLTRYFYLF PGN

Isoforms

- Isoform 2 of Caspase-4

Sequence View

        10         20         30         40         50         60 
MAENKHPDKP LKVLEQLGKE VLTEYLEKLV QSNVLKLKEE DKQKFNNAER SDKRWVFVDA 
        70         80         90        100        110        120 
MKKKHSKVGE MLLQTFFSVD PGSHHGEANL EMEEPEESLN TLKLCSPEEF TRLCREKTQE 
       130        140        150        160        170        180 
IYPIKEANGR TRKALIICNT EFKHLSLRYG ANFDIIGMKG LLEDLGYDVV VKEELTAEGM 
       190        200        210        220        230        240 
ESEMKDFAAL SEHQTSDSTF LVLMSHGTLH GICGTMHSEK TPDVLQYDTI YQIFNNCHCP 
       250        260        270        280        290        300 
GLRDKPKVII VQACRGGNSG EMWIRESSKP QLCRGVDLPR NMEADAVKLS HVEKDFIAFY 
       310        320        330        340        350        360 
STTPHHLSYR DKTGGSYFIT RLISCFRKHA CSCHLFDIFL KVQQSFEKAS IHSQMPTIDR 
       370    
ATLTRYFYLF PGN



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 1 Substrates

N-termini

    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P70343-81-unknown PGSHHG... 81 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P70343-286-unknown AVKLSH... 286 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates