P70343: Caspase-4
Protein names | - Caspase-4 - CASP-4 - 3.4.22.64 {ECO:0000250|UniProtKB:P49662} - Caspase-11 - CASP-11 - Protease ICH-3 {ECO:0000303|PubMed:8702803} - Caspase-4 subunit p10 - Caspase-4 subunit p20 |
---|---|
Gene names | Casp4 |
Organism | Mus musculus |
Protease Family | C14.012 |
Protease ID | C14.012 |
Chromosome location | |
UniProt ID | P70343 |
2
N-termini
3
C-termini
0
Cleavages
1
Substrates
Sequence
10 20 30 40 50 60
MAENKHPDKP LKVLEQLGKE VLTEYLEKLV QSNVLKLKEE DKQKFNNAER SDKRWVFVDA
70 80 90 100 110 120
MKKKHSKVGE MLLQTFFSVD PGSHHGEANL EMEEPEESLN TLKLCSPEEF TRLCREKTQE
130 140 150 160 170 180
IYPIKEANGR TRKALIICNT EFKHLSLRYG ANFDIIGMKG LLEDLGYDVV VKEELTAEGM
190 200 210 220 230 240
ESEMKDFAAL SEHQTSDSTF LVLMSHGTLH GICGTMHSEK TPDVLQYDTI YQIFNNCHCP
250 260 270 280 290 300
GLRDKPKVII VQACRGGNSG EMWIRESSKP QLCRGVDLPR NMEADAVKLS HVEKDFIAFY
310 320 330 340 350 360
STTPHHLSYR DKTGGSYFIT RLISCFRKHA CSCHLFDIFL KVQQSFEKAS IHSQMPTIDR
370
ATLTRYFYLF PGN
Isoforms
- Isoform 2 of Caspase-4Sequence View
10 20 30 40 50 60
MAENKHPDKP LKVLEQLGKE VLTEYLEKLV QSNVLKLKEE DKQKFNNAER SDKRWVFVDA
70 80 90 100 110 120
MKKKHSKVGE MLLQTFFSVD PGSHHGEANL EMEEPEESLN TLKLCSPEEF TRLCREKTQE
130 140 150 160 170 180
IYPIKEANGR TRKALIICNT EFKHLSLRYG ANFDIIGMKG LLEDLGYDVV VKEELTAEGM
190 200 210 220 230 240
ESEMKDFAAL SEHQTSDSTF LVLMSHGTLH GICGTMHSEK TPDVLQYDTI YQIFNNCHCP
250 260 270 280 290 300
GLRDKPKVII VQACRGGNSG EMWIRESSKP QLCRGVDLPR NMEADAVKLS HVEKDFIAFY
310 320 330 340 350 360
STTPHHLSYR DKTGGSYFIT RLISCFRKHA CSCHLFDIFL KVQQSFEKAS IHSQMPTIDR
370
ATLTRYFYLF PGN
Protein Neighborhood
Domains & Features
2 N-termini - 3 C-termini - 0 Cleavages - 1 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P70343-81-unknown | PGSHHG... | 81 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P70343-286-unknown | AVKLSH... | 286 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LSLRYG | 149 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000124402 | |||
...MWIRES | 266 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...LFPGN | 373 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP3_MOUSE | 175 | ETDS.|.SGTD | inferred from experiment | unknown | MEROPS | Yuan J | Kang SJ et al.:Dual role of caspase-11 in medi... (C14.012) | 10791975, |