P06151: L-lactate dehydrogenase A chain

General Information

Protein names	- L-lactate dehydrogenase A chain - LDH-A - 1.1.1.27 - LDH muscle subunit - LDH-M
Gene names	Ldha
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P06151

7 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATLKDQLIV NLLKEEQAPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVMEDKLKG
        70         80         90        100        110        120
EMMDLQHGSL FLKTPKIVSS KDYCVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
       130        140        150        160        170        180
IPNIVKYSPH CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
       190        200        210        220        230        240
HALSCHGWVL GEHGDSSVPV WSGVNVAGVS LKSLNPELGT DADKEQWKEV HKQVVDSAYE
       250        260        270        280        290        300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGINEDVFLS VPCILGQNGI
       310        320        330
SDVVKVTLTP EEEARLKKSA DTLWGIQKEL QF

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P06151-2-unknown	MATLKD...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P06151-2-unknown	MATLKD...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P06151-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P06151-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P06151-92-unknown	VIITAG...	92		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29629
P06151-253-unknown	GLSVAD...	253		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29630
P06151-255-unknown	SVADLA...	255		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28707
P06151-260-unknown	AESIMK...	260		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28708
P06151-303-unknown	VVKVTL...	303		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29631
P06151-303-unknown	VVKVTL...	303		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33236

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ANSKLV	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29629
...KQVVDS	236	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123356
...TSWAIG	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29630
...WAIGLS	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28707
...SVADLA	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28708
...NGISDV	302	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29631
...NGISDV	302	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33236
...KELQF	332	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	91	SKLV.\|.VIIT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> LDHA_MOUSE @91
CATE_MOUSE	252	WAIG.\|.GLSV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> LDHA_MOUSE @252
CATD_MOUSE	254	IGLS.\|.SVAD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> LDHA_MOUSE @254
CATD_MOUSE	259	ADLA.\|.AESI	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> LDHA_MOUSE @259
CATE_MOUSE	302	ISDV.\|.VVKV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> LDHA_MOUSE @302
MMP2_MOUSE	302	ISDV.\|.VVKV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)