O54988: STE20-like serine/threonine-protein kinase

General Information

Protein names	- STE20-like serine/threonine-protein kinase - STE20-like kinase - mSLK - 2.7.11.1 - Etk4 - STE20-related kinase SMAK - STE20-related serine/threonine-protein kinase - STE20-related kinase - Serine/threonine-protein kinase 2
Gene names	Slk
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O54988

5 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA
        70         80         90        100        110        120
AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM
       130        140        150        160        170        180
LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN
       190        200        210        220        230        240
TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP
       250        260        270        280        290        300
MRVLLKIAKS EPPTLAQPSK WSSNFKDFLR KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV
       310        320        330        340        350        360
RELIAEAKAE VTEEVEDGKE EDEEEEAENA LPIPANKRAS SDLSIASSEE DKLSQNACIL
       370        380        390        400        410        420
ESVSERTEQS TSEDKFSNKI LNEKPTTDGP EKAVDEHASD VNLETGAELN DQTVGIHENG
       430        440        450        460        470        480
REKKRPKLEN LPDTQDQQTV DVNSVSEENE NNRVTLETNT DCLKPEEDRN KENQETLESK
       490        500        510        520        530        540
LIQSEEINDT HIQTMDLVSQ ETGEKEADFQ AVDNEVGLTK EETQEKLGKD GTAQKVITSD
       550        560        570        580        590        600
RSSEVGTDEA LDDTQKAAEL SKAAQSGEGD EALAPTQTLA EKPTEGPEAG GAEEEPPGGE
       610        620        630        640        650        660
RVEDKQPEQQ PAVCEAEGQL TSTSETTRAT LEQPETDEVE QVSESNSIEE LERLVVTGAE
       670        680        690        700        710        720
ARALGSEGEA AATEVDLERK ENAQKVPVKA ESQAPAASQP SEPHPVLIPS ININSETTEN
       730        740        750        760        770        780
KEEMGALPKP ETILPPEPEH EKGNDTDSGT GSTVENSSGD LNLSISSFLS KAKDSGSVSL
       790        800        810        820        830        840
QETRRQKKTL KKTRKFIVDG VEVSVTTSKI VTDSDSKTEE LRFLRRQELR ELRLLQKEEQ
       850        860        870        880        890        900
RAQQQLNGKL QQQREQIFRR FEQEMLSKKR QYDQEIENLE KQQKQTIERL EQEHTNRLRD
       910        920        930        940        950        960
EAKRIKGEQE KELSKFQNVL KNRKKEVMNE VEKAPRELRR ELTKRRKEEL AQSQHAQEQE
       970        980        990       1000       1010       1020
FVQKQQQELD GSLKKIIQQQ KAELANIERE CLNNKQQLMR AREAAIWELE ERHLQEKHQL
      1030       1040       1050       1060       1070       1080
LKQQLKDQYF MQRHQLLKRH EKETEQMQRY NQRLIEELKN RQTQERARLP KIQRSEAKTR
      1090       1100       1110       1120       1130       1140
MAMFKKSLRI NSTATPDQDR EKIKQFAAQE EKRQKNERMA QHQKHESQMR DLQLQCEANV
      1150       1160       1170       1180       1190       1200
RELHQLQNEK CHLLVEHETQ KLKELDEEHS QELKEWREKL RPRKKTLEEE FARKLQEQEV
      1210       1220       1230
FFKMTGESEC LNPSAQSRIS KFYPIPTLHS TGS

Isoforms

- Isoform 2 of STE20-like serine/threonine-protein kinase

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O54988-1-unknown	MSFFNF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O54988-1-unknown	MSFFNF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89951
O54988-655-unknown	VVTGAE...	655	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29545
O54988-655-unknown	VVTGAE...	655	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155382
O54988-668-unknown	GEAAAT...	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28344
O54988-668-unknown	GEAAAT...	668	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155522
O54988-764-unknown	SISSFL...	764	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29547
O54988-764-unknown	SISSFL...	764	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156332
O54988-1202-unknown	FKMTGE...	1202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29549
O54988-1202-unknown	FKMTGE...	1202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28663
O54988-1202-unknown	FKMTGE...	1202	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157549

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELERLV	654	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29545
...ELERLV	654	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138817
...ALGSEG	667	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28344
...ALGSEG	667	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138960
...GDLNLS	763	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29547
...GDLNLS	763	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139805
...EQEVFF	1201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29549
...EQEVFF	1201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28663
...EQEVFF	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141048
...HSTGS	1233	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSTGS	1233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85569

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	654	ERLV.\|.VVTG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> SLK_MOUSE @654
CASP1_MOUSE	667	GSEG.\|.GEAA	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CATE_MOUSE	763	LNLS.\|.SISS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> SLK_MOUSE @763
CATE_MOUSE	1201	EVFF.\|.FKMT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> SLK_MOUSE @1201
CATD_MOUSE	1201	EVFF.\|.FKMT	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> SLK_MOUSE @1201

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)