P18760: Cofilin-1

General Information

Protein names	- Cofilin-1 - Cofilin, non-muscle isoform
Gene names	Cfl1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P18760

10 N-termini

6 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV
        70         80         90        100        110        120
GQTVDDPYTT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPENAP LKSKMIYASS
       130        140        150        160
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18760-2-unknown	MASGVA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18760-2-Acetylation	ASGVAV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18760-5-unknown	VAVSDG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33422
P18760-7-unmodified	VSDGVI...	7			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P18760-7-unknown	VSDGVI...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33423
P18760-9-unknown	DGVIKV...	9		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P18760-57-unknown	VGDVGQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29819
P18760-57-unknown	VGDVGQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28815
P18760-63-unknown	TVDDPY...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33424
P18760-71-unknown	FVKMLP...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28816
P18760-72-unknown	VKMLPD...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29820
P18760-72-unknown	VKMLPD...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28817

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASGVAV	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33423
...GKEILV	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29819
...GKEILV	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28815
...GDVGQT	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33424
...DPYTTF	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28816
...PYTTFV	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29820
...PYTTFV	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28817
...EGKPL	166	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	4	ASGV.\|.VAVS	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	6	GVAV.\|.VSDG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	56	EILV.\|.VGDV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> COF1_MOUSE @56
CATD_MOUSE	56	EILV.\|.VGDV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> COF1_MOUSE @56
MMP2_MOUSE	62	VGQT.\|.TVDD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	70	YTTF.\|.FVKM	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> COF1_MOUSE @70
CATE_MOUSE	71	TTFV.\|.VKML	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> COF1_MOUSE @71
CATD_MOUSE	71	TTFV.\|.VKML	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> COF1_MOUSE @71

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)