P09103: Protein disulfide-isomerase

General Information

Protein names	- Protein disulfide-isomerase - PDI - 5.3.4.1 - Cellular thyroid hormone-binding protein - Endoplasmic reticulum resident protein 59 - ER protein 59 - ERp59 - Prolyl 4-hydroxylase subunit beta - p55
Gene names	P4hb
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P09103

10 N-termini

6 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSRALLCLA LAWAARVGAD ALEEEDNVLV LKKSNFEEAL AAHKYLLVEF YAPWCGHCKA
        70         80         90        100        110        120
LAPEYAKAAA KLKAEGSEIR LAKVDATEES DLAQQYGVRG YPTIKFFKNG DTASPKEYTA
       130        140        150        160        170        180
GREADDIVNW LKKRTGPAAT TLSDTAAAES LVDSSEVTVI GFFKDVESDS AKQFLLAAEA
       190        200        210        220        230        240
IDDIPFGITS NSGVFSKYQL DKDGVVLFKK FDEGRNNFEG EITKEKLLDF IKHNQLPLVI
       250        260        270        280        290        300
EFTEQTAPKI FGGEIKTHIL LFLPKSVSDY DGKLSSFKRA AEGFKGKILF IFIDSDHTDN
       310        320        330        340        350        360
QRILEFFGLK KEECPAVRLI TLEEEMTKYK PESDELTAEK ITEFCHRFLE GKIKPHLMSQ
       370        380        390        400        410        420
EVPEDWDKQP VKVLVGANFE EVAFDEKKNV FVEFYAPWCG HCKQLAPIWD KLGETYKDHE
       430        440        450        460        470        480
NIIIAKMDST ANEVEAVKVH SFPTLKFFPA SADRTVIDYN GERTLDGFKK FLESGGQDGA
       490        500
GDDEDLDLEE ALEPDMEEDD DQKAVKDEL

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P09103-20-unknown	DALEEE...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09103-20-unknown	DALEEE...	20	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P09103-48-unknown	VEFYAP...	48	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P09103-72-unknown	LKAEGS...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33285
P09103-77-unknown	SEIRLA...	77	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P09103-82-unknown	AKVDAT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28727
P09103-82-unknown	AKVDAT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29657
P09103-93-unknown	AQQYGV...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29658
P09103-107-unknown	FKNGDT...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28728
P09103-107-unknown	FKNGDT...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29659
P09103-109-unknown	NGDTAS...	109	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P09103-168-unknown	SDSAKQ...	168	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P09103-208-unknown	FKKFDE...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28729
P09103-208-unknown	FKKFDE...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29660

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAAAKL	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33285
...SEIRLA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28727
...SEIRLA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29657
...EESDLA	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29658
...PTIKFF	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28728
...PTIKFF	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29659
...DGVVLF	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28729
...DGVVLF	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29660
...VKDEL	509	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	71	AAKL.\|.LKAE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	81	IRLA.\|.AKVD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PDIA1_MOUSE @81
CATE_MOUSE	81	IRLA.\|.AKVD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA1_MOUSE @81
CATE_MOUSE	92	SDLA.\|.AQQY	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA1_MOUSE @92
CATD_MOUSE	106	IKFF.\|.FKNG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PDIA1_MOUSE @106
CATE_MOUSE	106	IKFF.\|.FKNG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA1_MOUSE @106
CATD_MOUSE	207	VVLF.\|.FKKF	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PDIA1_MOUSE @207
CATE_MOUSE	207	VVLF.\|.FKKF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA1_MOUSE @207

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)