Q8VDM4: 26S proteasome non-ATPase regulatory subunit 2

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 2 - 26S proteasome regulatory subunit RPN1 - 26S proteasome regulatory subunit S2 - 26S proteasome subunit p97
Gene names	Psmd2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8VDM4

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEGGRDKTP VQSQQPSATT PSGADEKSSG KERRDAGEKD KEQELSEEDK QLQDELEMLV
        70         80         90        100        110        120
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKC
       130        140        150        160        170        180
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKAQ
       190        200        210        220        230        240
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV
       250        260        270        280        290        300
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
       310        320        330        340        350        360
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG
       370        380        390        400        410        420
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW
       430        440        450        460        470        480
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG
       490        500        510        520        530        540
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ
       550        560        570        580        590        600
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
       610        620        630        640        650        660
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI
       670        680        690        700        710        720
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE
       730        740        750        760        770        780
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP
       790        800        810        820        830        840
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL
       850        860        870        880        890        900
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYDL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8VDM4-1-Acetylation	MEEGGR...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8VDM4-12-unknown	QSQQPS...	12		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q8VDM4-144-unmodified	LVGSQE...	144			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q8VDM4-162-unknown	LAGEVA...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34122
Q8VDM4-728-unknown	AMGMVG...	728		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29273

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EYVRHL	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34122
...YNSIFA	727	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29273
...PNYDL	908	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	161	VRHL.\|.LAGE	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATD_MOUSE	727	SIFA.\|.AMGM	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PSMD2_MOUSE @727

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)