P68369: Tubulin alpha-1A chain

General Information

Protein names	- Tubulin alpha-1A chain - Alpha-tubulin 1 - Alpha-tubulin isotype M-alpha-1 - Tubulin alpha-1 chain - Detyrosinated tubulin alpha-1A chain
Gene names	Tuba1a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P68369

16 N-termini

9 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK
        70         80         90        100        110        120
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD
       130        140        150        160        170        180
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
       190        200        210        220        230        240
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA
       250        260        270        280        290        300
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN
       310        320        330        340        350        360
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP
       370        380        390        400        410        420
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
       430        440        450
AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 9 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P68369-1-unknown	MRECIS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68369-39-unmodified	DKTIGG...	39			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-52-unmodified	FFSETG...	52			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-66-unknown	VFVDLE...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33775
P68369-68-unknown	VDLEPT...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30308
P68369-69-unmodified	DLEPTV...	69			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P68369-69-unmodified	DLEPTV...	69			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-70-unknown	LEPTVI...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32385
P68369-85-Pyrrolidone carboxylic acid	QLFHPE...	85	pyrrolidone carboxylic acid-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P68369-92-unknown	LITGKE...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30309
P68369-92-unknown	LITGKE...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33776
P68369-93-unknown	ITGKED...	93		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30310
P68369-93-unknown	ITGKED...	93		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29064
P68369-194-unmodified	TLEHSD...	194			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-252-unknown	LTEFQT...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32386
P68369-327-unmodified	DVNAAI...	327			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-354-unmodified	GINYQP...	354			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-406-unmodified	HWYVGE...	406			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P68369-408-unknown	YVGEGM...	408		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33777

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HVPRAV	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33775
...PRAVFV	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30308
...AVFVDL	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32385
...FHPEQL	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30309
...FHPEQL	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33776
...HPEQLI	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30310
...HPEQLI	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29064
...ALNVDL	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32386
...AFVHWY	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33777
...EEGEEY	450	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31499
...EEGEEY	450	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EGEEY	451	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	65	PRAV.\|.VFVD	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TBA1A_MOUSE @65
CATE_MOUSE	67	AVFV.\|.VDLE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TBA1A_MOUSE @67
GRAB_MOUSE	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	91	PEQL.\|.LITG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TBA1A_MOUSE @91
MMP2_MOUSE	91	PEQL.\|.LITG	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TBA1A_MOUSE @91
CATE_MOUSE	92	EQLI.\|.ITGK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TBA1A_MOUSE @92
CATD_MOUSE	92	EQLI.\|.ITGK	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
GRAB_MOUSE	251	NVDL.\|.LTEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	407	VHWY.\|.YVGE	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TBA1A_MOUSE @407
CBPC1_MOUSE	450	GEEY.\|.Y	inferred from experiment	unknown	MEROPS	Fricker LD	Kalinina E et al.:A novel subfamily of mouse cyto... (M14.028)	17244818,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)