Q6URW6: Myosin-14
| Protein names | - Myosin-14 - Myosin heavy chain 14 - Myosin heavy chain, non-muscle IIc - Non-muscle myosin heavy chain IIc - NMHC II-C |
|---|---|
| Gene names | Myh14 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q6URW6 |
5
N-termini
3
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAVTMSVSG RKVASRPGPV PEAAQSFLYA PRTPNVGGPG GPQVEWTARR MVWVPSELHG
70 80 90 100 110 120
FEAAALRDEG EEEAEVELAE SGRRLRLPRD QIQRMNPPKF SKAEDMAELT CLNEASVLHN
130 140 150 160 170 180
LRERYYSGLI YTYSGLFCVV INPYKQLPIY TEAIVEMYRG KKRHEVPPHV YAVTEGAYRS
190 200 210 220 230 240
MLQDREDQSI LCTGESGAGK TENTKKVIQY LAHVASSPKG RKEPGVPASV STMSYGELER
250 260 270 280 290 300
QLLQANPILE AFGNAKTVKN DNSSRFGKFI RINFDIAGYI VGANIETYLL EKSRAIRQAK
310 320 330 340 350 360
DECSFHIFYQ LLGGAGEQLK ADLLLEPCSH YRFLTNGPSS SPGQERELFQ ETLESLRVLG
370 380 390 400 410 420
LLPEEITAML RTVSAVLQFG NIVLKKERNT DQATMPDNTA AQKLCRLLGL GVTDFSRALL
430 440 450 460 470 480
TPRIKVGRDY VQKAQTKEQA DFALEALAKA TYERLFRWLV LRLNRALDRS PRQGASFLGI
490 500 510 520 530 540
LDIAGFEIFQ LNSFEQLCIN YTNEKLQQLF NHTMFVLEQE EYQREGIPWT FLDFGLDLQP
550 560 570 580 590 600
CIDLIERPAN PPGLLALLDE ECWFPKATDK SFVEKVAQEQ GSHPKFQRPR NLRDQADFSV
610 620 630 640 650 660
LHYAGKVDYK ASEWLMKNMD PLNDNVAALL HQSTDRLTAE IWKDVEGIVG LEQVSSLGDG
670 680 690 700 710 720
PPGGRPRRGM FRTVGQLYKE SLSRLMATLS NTNPSFVRCI VPNHEKRAGK LEPRLVLDQL
730 740 750 760 770 780
RCNGVLEGIR ICRQGFPNRI LFQEFRQRYE ILTPNAIPKG FMDGKQACEK MIQALELDPN
790 800 810 820 830 840
LYRVGQSKIF FRAGVLAQLE EERDLKVTDI IVSFQAAARG YLARRAFQRR QQQQSALRVM
850 860 870 880 890 900
QRNCAAYLKL RNWQWWRLFI KVKPLLQVTR QDEVLQARAQ ELQKVQELQQ QSAREVGELQ
910 920 930 940 950 960
GRVAQLEEER TRLAEQLRAE AELCSEAEET RARLAARKQE LELVVTELEA RVGEEEECSR
970 980 990 1000 1010 1020
QLQSEKKRLQ QHIQELESHL EAEEGARQKL QLEKVTTEAK MKKFEEDLLL LEDQNSKLSK
1030 1040 1050 1060 1070 1080
ERRLLEERLA EFSSQAAEEE EKVKSLNKLR LKYEATISDM EDRLKKEEKG RQELEKLKRR
1090 1100 1110 1120 1130 1140
LDGESSELQE QMVEQKQRAE ELLAQLGRKE DELQAALLRA EEEGGARAQL LKSLREAQAG
1150 1160 1170 1180 1190 1200
LAEAQEDLEA ERVARAKAEK QRRDLGEELE ALRGELEDTL DSTNAQQELR SKREQEVTEL
1210 1220 1230 1240 1250 1260
KKALEEESRA HEVSMQELRQ RHSQALVEMA EQLEQARRGK GVWEKTRLSL EAEVSELKAE
1270 1280 1290 1300 1310 1320
LSSLQTSRQE GEQKRRRLES QLQEVQGRSS DSERARSEAA EKLQRAQAEL ESVSTALSEA
1330 1340 1350 1360 1370 1380
ESKAIRLGKE LSSAESQLHD TQELLQEETR AKLALGSRVR ALEAEAAGLR EQMEEEVVAR
1390 1400 1410 1420 1430 1440
ERAGRELQST QAQLSEWRRR QEEEAAVLEA GEEARRRAAR EAETLTQRLA EKTEAVERLE
1450 1460 1470 1480 1490 1500
RARRRLQQEL DDATVDLGQQ KQLLSTLEKK QRKFDQLLAE EKAAVLRAVE DRERIEAEGR
1510 1520 1530 1540 1550 1560
EREARALSLT RALEEEQEAR EELERQNRAL RAELEALLSS KDDVGKNVHE LERARKAAEQ
1570 1580 1590 1600 1610 1620
AASDLRTQVT ELEDELTAAE DAKLRLEVTV QALKAQHERD LQGRDDAGEE RRRQLAKQLR
1630 1640 1650 1660 1670 1680
DAEVERDEER KQRALAMAAR KKLELELEEL KAQTSAAGQG KEEAVKQLKK MQVQMKELWR
1690 1700 1710 1720 1730 1740
EVEETRSSRD EMFTLSRENE KKLKGLEAEV LRLQEELAAS DRARRQAQQD RDEMAEEVAS
1750 1760 1770 1780 1790 1800
GNLSKAATLE EKRQLEGRLS QLEEELEEEQ NNSELLKDHY RKLVLQVESL TTELSAERSF
1810 1820 1830 1840 1850 1860
SAKAESGRQQ LERQIQELRA RLGEEDAGAR ARQKMLIAAL ESKLAQAEEQ LEQESRERIL
1870 1880 1890 1900 1910 1920
SGKLVRRAEK RLKEVVLQVD EERRVADQVR DQLEKSNLRL KQLKRQLEEA EEEASRAQAG
1930 1940 1950 1960 1970 1980
RRRLQRELED VTESAESMNR EVTTLRNRLR RGPLTFTTRT VRQVFRLEEG VASDEEEAEG
1990 2000
AEPGSAPGQE PEAPPPATPQ
Isoforms
- Isoform 2 of Myosin-14 - Isoform 3 of Myosin-14Sequence View
10 20 30 40 50 60
MAAVTMSVSG RKVASRPGPV PEAAQSFLYA PRTPNVGGPG GPQVEWTARR MVWVPSELHG
70 80 90 100 110 120
FEAAALRDEG EEEAEVELAE SGRRLRLPRD QIQRMNPPKF SKAEDMAELT CLNEASVLHN
130 140 150 160 170 180
LRERYYSGLI YTYSGLFCVV INPYKQLPIY TEAIVEMYRG KKRHEVPPHV YAVTEGAYRS
190 200 210 220 230 240
MLQDREDQSI LCTGESGAGK TENTKKVIQY LAHVASSPKG RKEPGVPASV STMSYGELER
250 260 270 280 290 300
QLLQANPILE AFGNAKTVKN DNSSRFGKFI RINFDIAGYI VGANIETYLL EKSRAIRQAK
310 320 330 340 350 360
DECSFHIFYQ LLGGAGEQLK ADLLLEPCSH YRFLTNGPSS SPGQERELFQ ETLESLRVLG
370 380 390 400 410 420
LLPEEITAML RTVSAVLQFG NIVLKKERNT DQATMPDNTA AQKLCRLLGL GVTDFSRALL
430 440 450 460 470 480
TPRIKVGRDY VQKAQTKEQA DFALEALAKA TYERLFRWLV LRLNRALDRS PRQGASFLGI
490 500 510 520 530 540
LDIAGFEIFQ LNSFEQLCIN YTNEKLQQLF NHTMFVLEQE EYQREGIPWT FLDFGLDLQP
550 560 570 580 590 600
CIDLIERPAN PPGLLALLDE ECWFPKATDK SFVEKVAQEQ GSHPKFQRPR NLRDQADFSV
610 620 630 640 650 660
LHYAGKVDYK ASEWLMKNMD PLNDNVAALL HQSTDRLTAE IWKDVEGIVG LEQVSSLGDG
670 680 690 700 710 720
PPGGRPRRGM FRTVGQLYKE SLSRLMATLS NTNPSFVRCI VPNHEKRAGK LEPRLVLDQL
730 740 750 760 770 780
RCNGVLEGIR ICRQGFPNRI LFQEFRQRYE ILTPNAIPKG FMDGKQACEK MIQALELDPN
790 800 810 820 830 840
LYRVGQSKIF FRAGVLAQLE EERDLKVTDI IVSFQAAARG YLARRAFQRR QQQQSALRVM
850 860 870 880 890 900
QRNCAAYLKL RNWQWWRLFI KVKPLLQVTR QDEVLQARAQ ELQKVQELQQ QSAREVGELQ
910 920 930 940 950 960
GRVAQLEEER TRLAEQLRAE AELCSEAEET RARLAARKQE LELVVTELEA RVGEEEECSR
970 980 990 1000 1010 1020
QLQSEKKRLQ QHIQELESHL EAEEGARQKL QLEKVTTEAK MKKFEEDLLL LEDQNSKLSK
1030 1040 1050 1060 1070 1080
ERRLLEERLA EFSSQAAEEE EKVKSLNKLR LKYEATISDM EDRLKKEEKG RQELEKLKRR
1090 1100 1110 1120 1130 1140
LDGESSELQE QMVEQKQRAE ELLAQLGRKE DELQAALLRA EEEGGARAQL LKSLREAQAG
1150 1160 1170 1180 1190 1200
LAEAQEDLEA ERVARAKAEK QRRDLGEELE ALRGELEDTL DSTNAQQELR SKREQEVTEL
1210 1220 1230 1240 1250 1260
KKALEEESRA HEVSMQELRQ RHSQALVEMA EQLEQARRGK GVWEKTRLSL EAEVSELKAE
1270 1280 1290 1300 1310 1320
LSSLQTSRQE GEQKRRRLES QLQEVQGRSS DSERARSEAA EKLQRAQAEL ESVSTALSEA
1330 1340 1350 1360 1370 1380
ESKAIRLGKE LSSAESQLHD TQELLQEETR AKLALGSRVR ALEAEAAGLR EQMEEEVVAR
1390 1400 1410 1420 1430 1440
ERAGRELQST QAQLSEWRRR QEEEAAVLEA GEEARRRAAR EAETLTQRLA EKTEAVERLE
1450 1460 1470 1480 1490 1500
RARRRLQQEL DDATVDLGQQ KQLLSTLEKK QRKFDQLLAE EKAAVLRAVE DRERIEAEGR
1510 1520 1530 1540 1550 1560
EREARALSLT RALEEEQEAR EELERQNRAL RAELEALLSS KDDVGKNVHE LERARKAAEQ
1570 1580 1590 1600 1610 1620
AASDLRTQVT ELEDELTAAE DAKLRLEVTV QALKAQHERD LQGRDDAGEE RRRQLAKQLR
1630 1640 1650 1660 1670 1680
DAEVERDEER KQRALAMAAR KKLELELEEL KAQTSAAGQG KEEAVKQLKK MQVQMKELWR
1690 1700 1710 1720 1730 1740
EVEETRSSRD EMFTLSRENE KKLKGLEAEV LRLQEELAAS DRARRQAQQD RDEMAEEVAS
1750 1760 1770 1780 1790 1800
GNLSKAATLE EKRQLEGRLS QLEEELEEEQ NNSELLKDHY RKLVLQVESL TTELSAERSF
1810 1820 1830 1840 1850 1860
SAKAESGRQQ LERQIQELRA RLGEEDAGAR ARQKMLIAAL ESKLAQAEEQ LEQESRERIL
1870 1880 1890 1900 1910 1920
SGKLVRRAEK RLKEVVLQVD EERRVADQVR DQLEKSNLRL KQLKRQLEEA EEEASRAQAG
1930 1940 1950 1960 1970 1980
RRRLQRELED VTESAESMNR EVTTLRNRLR RGPLTFTTRT VRQVFRLEEG VASDEEEAEG
1990 2000
AEPGSAPGQE PEAPPPATPQ
10 20 30 40 50 60
MAAVTMSVSG RKVASRPGPV PEAAQSFLYA PRTPNVGGPG GPQVEWTARR MVWVPSELHG
70 80 90 100 110 120
FEAAALRDEG EEEAEVELAE SGRRLRLPRD QIQRMNPPKF SKAEDMAELT CLNEASVLHN
130 140 150 160 170 180
LRERYYSGLI YTYSGLFCVV INPYKQLPIY TEAIVEMYRG KKRHEVPPHV YAVTEGAYRS
190 200 210 220 230 240
MLQDREDQSI LCTGESGAGK TENTKKVIQY LAHVASSPKG RKEPGVPASV STMSYGELER
250 260 270 280 290 300
QLLQANPILE AFGNAKTVKN DNSSRFGKFI RINFDIAGYI VGANIETYLL EKSRAIRQAK
310 320 330 340 350 360
DECSFHIFYQ LLGGAGEQLK ADLLLEPCSH YRFLTNGPSS SPGQERELFQ ETLESLRVLG
370 380 390 400 410 420
LLPEEITAML RTVSAVLQFG NIVLKKERNT DQATMPDNTA AQKLCRLLGL GVTDFSRALL
430 440 450 460 470 480
TPRIKVGRDY VQKAQTKEQA DFALEALAKA TYERLFRWLV LRLNRALDRS PRQGASFLGI
490 500 510 520 530 540
LDIAGFEIFQ LNSFEQLCIN YTNEKLQQLF NHTMFVLEQE EYQREGIPWT FLDFGLDLQP
550 560 570 580 590 600
CIDLIERPAN PPGLLALLDE ECWFPKATDK SFVEKVAQEQ GSHPKFQRPR NLRDQADFSV
610 620 630 640 650 660
LHYAGKVDYK ASEWLMKNMD PLNDNVAALL HQSTDRLTAE IWKDVEGIVG LEQVSSLGDG
670 680 690 700 710 720
PPGGRPRRGM FRTVGQLYKE SLSRLMATLS NTNPSFVRCI VPNHEKRAGK LEPRLVLDQL
730 740 750 760 770 780
RCNGVLEGIR ICRQGFPNRI LFQEFRQRYE ILTPNAIPKG FMDGKQACEK MIQALELDPN
790 800 810 820 830 840
LYRVGQSKIF FRAGVLAQLE EERDLKVTDI IVSFQAAARG YLARRAFQRR QQQQSALRVM
850 860 870 880 890 900
QRNCAAYLKL RNWQWWRLFI KVKPLLQVTR QDEVLQARAQ ELQKVQELQQ QSAREVGELQ
910 920 930 940 950 960
GRVAQLEEER TRLAEQLRAE AELCSEAEET RARLAARKQE LELVVTELEA RVGEEEECSR
970 980 990 1000 1010 1020
QLQSEKKRLQ QHIQELESHL EAEEGARQKL QLEKVTTEAK MKKFEEDLLL LEDQNSKLSK
1030 1040 1050 1060 1070 1080
ERRLLEERLA EFSSQAAEEE EKVKSLNKLR LKYEATISDM EDRLKKEEKG RQELEKLKRR
1090 1100 1110 1120 1130 1140
LDGESSELQE QMVEQKQRAE ELLAQLGRKE DELQAALLRA EEEGGARAQL LKSLREAQAG
1150 1160 1170 1180 1190 1200
LAEAQEDLEA ERVARAKAEK QRRDLGEELE ALRGELEDTL DSTNAQQELR SKREQEVTEL
1210 1220 1230 1240 1250 1260
KKALEEESRA HEVSMQELRQ RHSQALVEMA EQLEQARRGK GVWEKTRLSL EAEVSELKAE
1270 1280 1290 1300 1310 1320
LSSLQTSRQE GEQKRRRLES QLQEVQGRSS DSERARSEAA EKLQRAQAEL ESVSTALSEA
1330 1340 1350 1360 1370 1380
ESKAIRLGKE LSSAESQLHD TQELLQEETR AKLALGSRVR ALEAEAAGLR EQMEEEVVAR
1390 1400 1410 1420 1430 1440
ERAGRELQST QAQLSEWRRR QEEEAAVLEA GEEARRRAAR EAETLTQRLA EKTEAVERLE
1450 1460 1470 1480 1490 1500
RARRRLQQEL DDATVDLGQQ KQLLSTLEKK QRKFDQLLAE EKAAVLRAVE DRERIEAEGR
1510 1520 1530 1540 1550 1560
EREARALSLT RALEEEQEAR EELERQNRAL RAELEALLSS KDDVGKNVHE LERARKAAEQ
1570 1580 1590 1600 1610 1620
AASDLRTQVT ELEDELTAAE DAKLRLEVTV QALKAQHERD LQGRDDAGEE RRRQLAKQLR
1630 1640 1650 1660 1670 1680
DAEVERDEER KQRALAMAAR KKLELELEEL KAQTSAAGQG KEEAVKQLKK MQVQMKELWR
1690 1700 1710 1720 1730 1740
EVEETRSSRD EMFTLSRENE KKLKGLEAEV LRLQEELAAS DRARRQAQQD RDEMAEEVAS
1750 1760 1770 1780 1790 1800
GNLSKAATLE EKRQLEGRLS QLEEELEEEQ NNSELLKDHY RKLVLQVESL TTELSAERSF
1810 1820 1830 1840 1850 1860
SAKAESGRQQ LERQIQELRA RLGEEDAGAR ARQKMLIAAL ESKLAQAEEQ LEQESRERIL
1870 1880 1890 1900 1910 1920
SGKLVRRAEK RLKEVVLQVD EERRVADQVR DQLEKSNLRL KQLKRQLEEA EEEASRAQAG
1930 1940 1950 1960 1970 1980
RRRLQRELED VTESAESMNR EVTTLRNRLR RGPLTFTTRT VRQVFRLEEG VASDEEEAEG
1990 2000
AEPGSAPGQE PEAPPPATPQ
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q6URW6-1-unknown | MAAVTM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81963 | |||
| Q6URW6-1-unknown | MAAVTM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81964 | |||
| Q6URW6-2-unknown | MAAVTM... | 1 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| Q6URW6-2-unknown | MAAVTM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q6URW6-2-Acetylation | AAVTMS... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
| Q6URW6-2-Acetylation | AAVTMS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110763 | ||
| Q6URW6-2-Acetylation | AAVTMS... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110764 | ||
| Q6URW6-2-Acetylation | AAVTMS... | 2 | acetylation- | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | ||
| Q6URW6-250-unknown | EAFGNA... | 250 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29211 | |||
| Q6URW6-250-unknown | EAFGNA... | 250 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30644 | |||
| Q6URW6-250-unknown | EAFGNA... | 250 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148163 | |||
| Q6URW6-250-unknown | EAFGNA... | 250 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148164 | |||
| Q6URW6-252-unknown | FGNAKT... | 252 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29214 | |||
| Q6URW6-252-unknown | FGNAKT... | 252 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148235 | |||
| Q6URW6-252-unknown | FGNAKT... | 252 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148236 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...ANPILE | 249 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29211 | |||
| ...ANPILE | 249 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30644 | |||
| ...PILEAF | 251 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29214 | |||
| ...PATPQ | 2000 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...PATPQ | 2000 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77581 | |||
| ...PATPQ | 2000 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77582 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CATD_MOUSE | 249 | PILE.|.EAFG | inferred from experiment | unknown | MEROPS | Zornig M | Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009) | 22388353, |
| CATE_MOUSE | 249 | PILE.|.EAFG | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> MYH14_MOUSE @249 | ||
| CATD_MOUSE | 251 | LEAF.|.FGNA | inferred from experiment | unknown | MEROPS | Zornig M | Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009) | 22388353, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|