Q61937: Nucleophosmin

General Information

Protein names	- Nucleophosmin - NPM - Nucleolar phosphoprotein B23 - Nucleolar protein NO38 - Numatrin
Gene names	Npm1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61937

11 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV
        70         80         90        100        110        120
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE
       130        140        150        160        170        180
EDAESEDEDE EDVKLLGMSG KRSAPGGGNK VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF
       190        200        210        220        230        240
DEEETEEKVP VKKSVRDTPA KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS
       250        260        270        280        290
SVEDIKAKMQ ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL

Isoforms

Sequence View

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q61937-1-Acetylation	MEDSMD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q61937-9-unknown	MSPLRP...	9		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q61937-23-unknown	LKADKD...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33964
Q61937-33-unknown	VDNDEN...	33			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q61937-33-unknown	VDNDEN...	33		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q61937-33-unknown	VDNDEN...	33		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q61937-67-unknown	YEGSPI...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33965
Q61937-84-unknown	QPTVSL...	84		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q61937-133-unknown	VKLLGM...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30535
Q61937-133-unknown	VKLLGM...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29170
Q61937-181-unknown	DEEETE...	181		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30536
Q61937-181-unknown	DEEETE...	181		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29171
Q61937-183-unknown	EETEEK...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30537
Q61937-184-unknown	ETEEKV...	184		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30538
Q61937-198-unknown	TPAKNA...	198		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28576

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFGCEL	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33964
...AEAMNY	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33965
...EDEEDV	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30535
...EDEEDV	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29170
...DDDDFD	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30536
...DDDDFD	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29171
...DDFDEE	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30537
...DFDEEE	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30538
...KSVRDT	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28576
...WRKSL	292	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	22	GCEL.\|.LKAD	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	66	AMNY.\|.YEGS	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> NPM_MOUSE @66
CATE_MOUSE	132	EEDV.\|.VKLL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> NPM_MOUSE @132
CATD_MOUSE	132	EEDV.\|.VKLL	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> NPM_MOUSE @132
CATE_MOUSE	180	DDFD.\|.DEEE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> NPM_MOUSE @180
CATD_MOUSE	180	DDFD.\|.DEEE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> NPM_MOUSE @180
CATE_MOUSE	182	FDEE.\|.EETE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> NPM_MOUSE @182
CATE_MOUSE	183	DEEE.\|.ETEE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> NPM_MOUSE @183
CASP7_MOUSE	197	VRDT.\|.TPAK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)