Q61316: Heat shock 70 kDa protein 4

General Information

Protein names	- Heat shock 70 kDa protein 4 - Heat shock 70-related protein APG-2
Gene names	Hspa4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61316

10 N-termini

10 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA AAKSQVISNA
        70         80         90        100        110        120
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM
       130        140        150        160        170        180
LLSKLKETAE SVLKKPVVDC VVSVPSFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA
       190        200        210        220        230        240
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL
       250        260        270        280        290        300
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT
       310        320        330        340        350        360
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK
       370        380        390        400        410        420
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGLSDCEVF
       430        440        450        460        470        480
PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV
       490        500        510        520        530        540
KVRVNVHGIF SVSSAALVEV HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT
       550        560        570        580        590        600
PAENKAESEE METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE
       610        620        630        640        650        660
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT LKLEDTENWL
       670        680        690        700        710        720
YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF EELGKQIQQY MKVISSFKNK
       730        740        750        760        770        780
EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL NLQNKQSLTV DPVVKTKEIE AKIKELTSIC
       790        800        810        820        830        840
SPIISKPKPK VEPPKEEPKH AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI

D

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 10 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q61316-1-unknown	MSVVGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61316-26-unknown	IANEYS...	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30504
Q61316-98-unknown	LTGIKV...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33950
Q61316-183-unknown	IYKQDL...	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33951
Q61316-338-unknown	VEIVGG...	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30505
Q61316-357-unknown	FFGKEL...	357	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33952
Q61316-381-unknown	AILSPA...	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30506
Q61316-598-unknown	YTENEG...	598	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30507
Q61316-677-unknown	AELKSL...	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30508
Q61316-677-unknown	AELKSL...	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29155
Q61316-679-unknown	LKSLGQ...	679	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34633
Q61316-679-unknown	LKSLGQ...	679	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33953

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGIETI	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30504
...QLPTGL	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33950
...ALAYGI	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33951
...EDIYAV	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30505
...EKISKF	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33952
...CALQCA	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30506
...EMLALY	597	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30507
...YVDKLA	676	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30508
...YVDKLA	676	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29155
...DKLAEL	678	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34633
...DKLAEL	678	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33953
...EMDID	841	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	25	IETI.\|.IANE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP74_MOUSE @25
MMP2_MOUSE	97	PTGL.\|.LTGI	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	182	AYGI.\|.IYKQ	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	337	IYAV.\|.VEIV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP74_MOUSE @337
MMP2_MOUSE	356	ISKF.\|.FFGK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	380	LQCA.\|.AILS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP74_MOUSE @380
CATE_MOUSE	597	LALY.\|.YTEN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP74_MOUSE @597
CATE_MOUSE	676	DKLA.\|.AELK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP74_MOUSE @676
CATD_MOUSE	676	DKLA.\|.AELK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HSP74_MOUSE @676
MMP9_MOUSE	678	LAEL.\|.LKSL	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	678	LAEL.\|.LKSL	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)