P16627: Heat shock 70 kDa protein 1-like

General Information

Protein names	- Heat shock 70 kDa protein 1-like - Heat shock 70 kDa protein 1L - Heat shock 70 kDa-like protein 1 - Spermatid-specific heat shock protein 70
Gene names	Hspa1l
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P16627

8 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAANKGMAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ
        70         80         90        100        110        120
VAMNPQNTVF DAKRLIGRKF NDPVVQSDMK LWPFQVINEA GKPKVMVSYK GEKKAFYPEE
       130        140        150        160        170        180
ISSMVLTKMK ETAEAFLGHN VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA
       190        200        210        220        230        240
AAIAYGLDKG SHGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV
       250        260        270        280        290        300
SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT
       310        320        330        340        350        360
RARFEELCAD LFRGTLEPVE KSLRDAKMDK AKIHDIVLVG GSTRIPKVQK LLQDYFNGRD
       370        380        390        400        410        420
LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTVLIKRNS
       430        440        450        460        470        480
TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTRDNNLLGR FDLTGIPPAP RGVPQIEVTF
       490        500        510        520        530        540
DIDANGILNV TAMDKSTGKA NKITITNDKG RLSKEEIERM VQEAERYKAE DEGQREKIAA
       550        560        570        580        590        600
KNALESYAFN MKSAVGDEGL KDKISESDKK KILDKCNEVL SWLEANQLAE KDEFDHKRKE
       610        620        630        640
LENMCNPIIT KLYQSGCTGP TCTPGYTPGR AATGPTIEEV D

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P16627-1-unknown	MAANKG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16627-20-unmodified	VGVFQH...	20			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P16627-30-unknown	IIANDQ...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29748
P16627-30-unknown	IIANDQ...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33390
P16627-44-unknown	VAFTDT...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29749
P16627-151-unmodified	YFNDSQ...	151			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P16627-225-unmodified	AGDTHL...	225			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P16627-419-Acetylation	NSTIPT...	419	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P16627-442-unknown	IQVYEG...	442		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28775

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HGKVEI	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29748
...HGKVEI	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33390
...TTPSYV	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29749
...QPGVLI	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28775
...IEEVD	641	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	29	KVEI.\|.IIAN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HS71L_MOUSE @29
MMP2_MOUSE	29	KVEI.\|.IIAN	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	43	PSYV.\|.VAFT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HS71L_MOUSE @43
CATD_MOUSE	441	GVLI.\|.IQVY	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)